US 12,390,497 B2
Microbial strains for virus inhibition
Michael R. King, Oak Creek, WI (US); Sona Son, Cudahy, WI (US); Nathan Robert Augspurger, Noblesville, IN (US); Joel Dean Spencer, Westfield, IN (US); and Kyle Leistikow, Franklin, WI (US)
Assigned to MICROBIAL DISCOVERY GROUP, LLC, Franklin, WI (US); and UNITED ANIMAL HEALTH, INC., Sheridan, IN (US)
Appl. No. 17/440,300
Filed by MICROBIAL DISCOVERY GROUP, LLC, Franklin, WI (US); and UNITED ANIMAL HEALTH, INC., Sheridan, IN (US)
PCT Filed Mar. 19, 2020, PCT No. PCT/US2020/023586
§ 371(c)(1), (2) Date Sep. 17, 2021,
PCT Pub. No. WO2020/191173, PCT Pub. Date Sep. 24, 2020.
Claims priority of provisional application 62/820,667, filed on Mar. 19, 2019.
Prior Publication US 2022/0143109 A1, May 12, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/742 (2015.01); A61K 9/00 (2006.01); A61K 38/46 (2006.01); A61K 38/47 (2006.01); A61K 38/48 (2006.01); A61P 31/14 (2006.01)
CPC A61K 35/742 (2013.01) [A61K 9/0056 (2013.01); A61K 38/465 (2013.01); A61K 38/47 (2013.01); A61K 38/48 (2013.01); A61P 31/14 (2018.01)] 11 Claims
 
1. A method of feeding an animal to reduce the risk of viral infection, the method comprising the step of administering to the animal a feed composition or drinking water comprising an effective amount of an additive comprising theisolated Bacillus strain A12, assigned accession no. NRRL B-67516, and
one or more isolated Bacillus strains selected from the group consisting of Bacillus strain 54, assigned accession no. NRRL B-67517, Bacillus strain 681, assigned accession no. NRRL B-67515, Bacillus strain 721, assigned accession no. NRRL B-67514, Bacillus strain 300, assigned accession no. NRRL B-50943, Bacillus strain 101, assigned accession no. NRRL B-67218, Bacillus strain 235, assigned accession no. NRRL B-67219, Bacillus strain 86, assigned accession no. NRRL B-50944-Bacillus strain 102, assigned accession no. NRRL B-67276 and Bacillus strain 177, assigned accession no. NRRL B-67275, and combinations thereof,
wherein administering the Bacillus strains causes virus inhibition in the animal.