US 12,390,409 B2
Use of ambroxol to improve skin barrier function
Stephen Anderson, Princeton, NJ (US)
Assigned to NeueRe, LLC, Princeton, NJ (US)
Filed by NeueRe, LLC, Princeton, NJ (US)
Filed on Jun. 30, 2023, as Appl. No. 18/345,292.
Application 18/345,292 is a continuation of application No. 17/124,798, filed on Dec. 17, 2020, granted, now 11,730,690.
Application 17/124,798 is a continuation of application No. 16/595,621, filed on Oct. 8, 2019, granted, now 10,894,008, issued on Jan. 19, 2021.
Application 16/595,621 is a continuation of application No. PCT/US2019/015137, filed on Jan. 25, 2019.
Claims priority of provisional application 62/622,375, filed on Jan. 26, 2018.
Prior Publication US 2023/0346671 A1, Nov. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 8/60 (2006.01); A61K 8/44 (2006.01); A61Q 5/00 (2006.01); A61Q 19/00 (2006.01); A61Q 19/08 (2006.01)
CPC A61K 8/60 (2013.01) [A61K 8/44 (2013.01); A61Q 5/00 (2013.01); A61Q 19/007 (2013.01); A61Q 19/08 (2013.01)] 22 Claims
 
1. A method of improving skin barrier function in a subject, wherein said method comprises topically administering a composition of ambroxol in a controlled-release formulation, wherein said controlled release formulation doses said subject at a rate to maintain a concentration of less than 0.1% (w/w) of ambroxol in solution, and wherein said improvement in skin barrier function is measured by:
1) a reduction in the signs of aging (or premature aging),
2) a decrease in the aging process of the skin,
3) a reduction in the appearance of lines and/or wrinkles,
4) a decrease in skin sagging,
5) an improvement and/or promotion in skin elasticity or suppleness,
6) a reduction in sun damage,
7) a reduction in stretch marks,
8) a reduction in the appearance of scars,
9) a reduction in the appearance of burns,
10) a reduction in the appearance of blemishes (e.g. acne),
11) a reduction in the appearance of dark circles,
12) a reduction in the appearance of age spots,
13) a reduction in the appearance of puffiness,
14) a prevention in water loss of the skin, and/or
15) an increase in moisturization.