US 12,390,273 B2
Surface and subsurface tumor mapping for computer-guided laser surgery
Jigar Patel, Seattle, WA (US); Weston Ross, Durham, NC (US); and Patrick Codd, Durham, NC (US)
Assigned to Duke University, Durham, NC (US)
Filed by Duke University, Durham, NC (US)
Filed on Dec. 23, 2022, as Appl. No. 18/088,304.
Application 18/088,304 is a continuation of application No. PCT/US2021/039877, filed on Jun. 30, 2021.
Claims priority of provisional application 63/045,919, filed on Jun. 30, 2020.
Prior Publication US 2023/0127514 A1, Apr. 27, 2023
Int. Cl. A61B 18/20 (2006.01); A61B 18/00 (2006.01); A61B 34/10 (2016.01)
CPC A61B 18/203 (2013.01) [A61B 34/10 (2016.02); A61B 2018/00404 (2013.01); A61B 2018/00452 (2013.01); A61B 2018/00696 (2013.01); A61B 2018/00904 (2013.01); A61B 2034/107 (2016.02)] 20 Claims
OG exemplary drawing
 
17. A non-transitory computer-readable storage medium having stored thereon instructions which, when executed by one or more processors, cause the one or more processors to:
capture, via at least one imaging probe or sensor, a biomedical image of a tissue region;
automatically determine, via the one or more processors based on the biomedical image, a three-dimensional vasculature structure associated with the tissue region, the three-dimensional vasculature structure including a map of one or more blood vessels that provide blood flow to the tissue region;
automatically determine, using a trained machine learning (ML) model based on the three-dimensional vasculature structure, one or more laser parameters for configuring at least one laser to deliver laser energy to at least one blood vessel of the one or more blood vessels within a targeted area of the tissue region, the one or more laser parameters including at least one of power, fluence, depth, spot size, pulse width, or wavelength; and
configure the at least one laser to deliver the laser energy, under control of the one or more processors, to the at least one blood vessel to halt blood flow to the targeted area within the tissue region.