| US 11,090,660 B2 | ||
| Hyper efficient separations device | ||
| Mark Hayes, Gilbert, AZ (US); Claire Crowther, Tempe, AZ (US); and Paul Jones, Mesa, AZ (US) | ||
| Assigned to ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US); and NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT, Bethesda, MD (US) | ||
| Appl. No. 16/324,324 | ||
| Filed by Arizona Board of Regents on behalf of Arizona State University, Scottsdale, AZ (US) | ||
| PCT Filed Aug. 10, 2017, PCT No. PCT/US2017/046217 § 371(c)(1), (2) Date Feb. 8, 2019, PCT Pub. No. WO2018/031722, PCT Pub. Date Feb. 15, 2018. |
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| Claims priority of provisional application 62/372,846, filed on Aug. 10, 2016. | ||
| Prior Publication US 2019/0168237 A1, Jun. 6, 2019 | ||
| Int. Cl. B03C 5/00 (2006.01); B03C 5/02 (2006.01); G01N 27/447 (2006.01); G01N 15/14 (2006.01); B01L 3/00 (2006.01); G01N 15/10 (2006.01) | ||
| CPC B03C 5/026 (2013.01) [B01L 3/502753 (2013.01); B03C 5/005 (2013.01); G01N 15/1056 (2013.01); G01N 15/1484 (2013.01); G01N 27/447 (2013.01); G01N 27/44791 (2013.01); B01L 2400/0424 (2013.01); B01L 2400/086 (2013.01); G01N 2015/1006 (2013.01)] | 18 Claims |
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1. A hyper-resolution insulator-based dielectrophoresis device for separating an analyte from a fluid, the device comprising:
a fluid flow channel disposed on a substrate, the fluid flow channel being defined by a first wall, a second wall spaced from the first wall, at least one fluid inlet, and at least one fluid outlet, the first wall including an insulating flow structure extending toward the second wall thereby defining a constriction in the fluid flow channel between the first wall and the second wall, the insulating flow structure comprising a base section and a plurality of projections extending from the base section toward the second wall;
electrodes in electrical communication with the at least one fluid inlet and the at least one fluid outlet of the fluid flow channel, wherein the electrodes are positioned to generate a spatially non-uniform electric field across the insulating flow structure of the fluid flow channel to exert a dielectrophoretic force on particles suspended in the fluid within the fluid flow channel, and
a power supply connected to each of the electrodes to generate an electric field within the fluid flow channel,
wherein the base section is elliptically shaped and the plurality of projections are elliptically shaped.
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