US 12,387,622 B2
Systems and methods for modeling veins and associated blood vessel components
Abhishek Jain, Cypress, TX (US); and Navaneeth Krishna Rajeeva Pandian, College Station, TX (US)
Assigned to The Texas A&M University System, College Station, TX (US)
Filed by The Texas A&M University System, College Station, TX (US)
Filed on Jun. 11, 2024, as Appl. No. 18/739,567.
Application 18/739,567 is a continuation of application No. 16/778,947, filed on Jan. 31, 2020, granted, now 12,039,885.
Claims priority of provisional application 62/800,163, filed on Feb. 1, 2019.
Prior Publication US 2024/0331572 A1, Oct. 3, 2024
Int. Cl. G09B 23/32 (2006.01); C12N 5/071 (2010.01); G09B 23/30 (2006.01)
CPC G09B 23/306 (2013.01) [C12N 5/069 (2013.01); G09B 23/303 (2013.01); G09B 23/32 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A microfluidic chip for modelling flow through a vein, comprising:
an artificially fabricated body comprising a microchannel extending between a fluid inlet and a fluid outlet, wherein at least a portion of the microchannel is coated with endothelial cells that form vascular lumen; and
a venous valve formed in the artificially fabricated body and positioned along the microchannel, wherein the venous valve comprises a pair of leaflets defining a pair of cusps of the venous valve, and a flow channel positioned between the leaflets.