US 12,385,026 B2
Stabilized alpha-galactosidase and uses thereof
Avidor Shulman, Rakefet (IL); Ilya Ruderfer, Carmiel (IL); Tehila Ben-Moshe, Koranit (IL); Talia Shekhter, Petach-Tikva (IL); Yaniv Azulay, Akko (IL); Tali Kizhner, Atzmon-Segev (IL); and Yoseph Shaaltiel, Timrat (IL)
Assigned to Protalix Ltd., Carmiel (IL)
Filed by Protalix Ltd., Carmiel (IL)
Filed on Apr. 8, 2022, as Appl. No. 17/716,348.
Application 17/716,348 is a continuation of application No. 17/391,208, filed on Aug. 2, 2021, abandoned.
Application 17/391,208 is a continuation of application No. 17/111,464, filed on Dec. 3, 2020, abandoned.
Application 17/111,464 is a continuation of application No. 16/356,238, filed on Mar. 18, 2019, granted, now 10,870,842.
Application 16/356,238 is a continuation of application No. 15/636,753, filed on Jun. 29, 2017, granted, now 10,280,414.
Application 15/636,753 is a continuation of application No. 14/936,720, filed on Nov. 10, 2015, granted, now 9,708,595.
Application 14/936,720 is a continuation of application No. 13/582,482, granted, now 9,194,011, previously published as PCT/IL2011/000209, filed on Mar. 2, 2011.
Application 13/582,482 is a continuation in part of application No. PCT/IL2010/000956, filed on Nov. 17, 2010.
Claims priority of provisional application 61/434,499, filed on Jan. 20, 2011.
Claims priority of provisional application 61/434,503, filed on Jan. 20, 2011.
Claims priority of provisional application 61/309,487, filed on Mar. 2, 2010.
Claims priority of provisional application 61/261,787, filed on Nov. 17, 2009.
Prior Publication US 2023/0074255 A1, Mar. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 9/40 (2006.01); A61K 38/00 (2006.01)
CPC C12N 9/2465 (2013.01) [C12Y 302/01022 (2013.01); A61K 38/00 (2013.01)] 16 Claims
 
1. A stabilized form of α-galactosidase comprising two α-galactosidase monomers covalently linked to one another via a linking moiety, wherein each of said two α-galactosidase monomers has the amino acid sequence of SEQ ID NO: 3.