US 12,384,808 B2
Modulators of TNF-α activity
Toufike Kanouni, Palm Beach Gardens, FL (US); and Chris De Savi, Stow, MA (US)
Assigned to FORWARD THERAPEUTICS, INC., Palm Beach Gardens, FL (US)
Filed by Forward Therapeutics, Inc., Palm Beach Gardens, FL (US)
Filed on Nov. 21, 2023, as Appl. No. 18/516,560.
Claims priority of provisional application 63/518,062, filed on Aug. 7, 2023.
Claims priority of provisional application 63/384,919, filed on Nov. 23, 2022.
Prior Publication US 2024/0247014 A1, Jul. 25, 2024
Int. Cl. C07F 9/6561 (2006.01); C07B 59/00 (2006.01); C07F 9/6568 (2006.01); C07F 9/6571 (2006.01)
CPC C07F 9/6561 (2013.01) [C07B 59/002 (2013.01); C07F 9/65685 (2013.01); C07F 9/657163 (2013.01); C07B 2200/05 (2013.01)] 22 Claims
 
1. A compound, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, selected from the group consisting of:
(7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one;
(7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one;
(7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one;
(7R, 14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one;
(7R, 14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one;
(7R, 14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)phenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one;
(7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one;
(7R, 14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one;
(7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-9-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one; and
(7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-12-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one.