US 12,384,792 B2
Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
Louis Grenier, Newton, MA (US); Andre Lescarbeau, Somerville, MA (US); Praveen Sharma, Arlington, MA (US); and Daniel G. Genov, Boston, MA (US)
Assigned to Twelve Therapeutics, Inc., New York, NY (US)
Filed by Twelve Therapeutics, Inc., New York, NY (US)
Filed on Feb. 21, 2024, as Appl. No. 18/583,627.
Application 18/583,627 is a division of application No. 17/578,309, filed on Jan. 18, 2022, granted, now 11,939,333.
Application 17/578,309 is a division of application No. 16/197,195, filed on Nov. 20, 2018, granted, now 11,247,995, issued on Feb. 15, 2022.
Application 16/197,195 is a division of application No. 15/264,417, filed on Sep. 13, 2016, granted, now 10,160,761, issued on Dec. 25, 2018.
Claims priority of provisional application 62/218,493, filed on Sep. 14, 2015.
Claims priority of provisional application 62/218,486, filed on Sep. 14, 2015.
Prior Publication US 2024/0317763 A1, Sep. 26, 2024
Int. Cl. C07D 487/04 (2006.01); A61K 9/48 (2006.01); A61K 31/519 (2006.01); C07D 231/12 (2006.01); C07D 231/38 (2006.01); C07D 401/06 (2006.01)
CPC C07D 487/04 (2013.01) [A61K 9/485 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 31/519 (2013.01); C07D 231/12 (2013.01); C07D 231/38 (2013.01); C07D 401/06 (2013.01); C07B 2200/13 (2013.01)] 9 Claims
 
1. A process of preparing amorphous form of a compound of Formula (I):

OG Complex Work Unit Chemistry
comprising:
(i) dissolving a solid form comprising a polymorphic form of the compound of formula (I) in one or more solvents to form a solution, wherein the polymorphic form has an XRPD pattern comprising peaks at 16.8, 23.6, and 25.6 degrees 2θ, plus or minus 0.2; and
(ii) removing the solvent of the solution to provide the amorphous form of the compound of formula (I).