US 12,383,753 B2
Method and system of sensitizing cancer cells to chemical treatment by plasma based activation
Dayun Yan, Ashburn, VA (US); Michael Keidar, Baltimore, MD (US); and Eda Gjika, Washington, DC (US)
Assigned to George Washington University, Washington, DC (US)
Appl. No. 15/734,149
Filed by The George Washington University, Washington, DC (US)
PCT Filed May 31, 2019, PCT No. PCT/US2019/034999
§ 371(c)(1), (2) Date Dec. 1, 2020,
PCT Pub. No. WO2019/232438, PCT Pub. Date Dec. 5, 2019.
Claims priority of provisional application 62/679,174, filed on Jun. 1, 2018.
Prior Publication US 2021/0213297 A1, Jul. 15, 2021
Int. Cl. A61N 1/44 (2006.01); A61K 31/4188 (2006.01); A61K 33/40 (2006.01); A61K 41/00 (2020.01); H01J 37/32 (2006.01)
CPC A61N 1/44 (2013.01) [A61K 31/4188 (2013.01); A61K 33/40 (2013.01); A61K 41/00 (2013.01); H01J 37/32366 (2013.01); H01J 37/32449 (2013.01); H01J 37/32825 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for sensitization treatment of an area having cancerous cells and normal cells, comprising:
a plasma device to generate a cold atmospheric plasma jet between an anode and a cathode, the generated plasma jet directed at the area having cancerous cells and normal cells;
a controller coupled to a power supply and a gas supply to control power to the anode and cathode, and gas supply to the plasma device, the controller activating the cold atmospheric plasma jet for a sufficient time to sensitize the cells via a reactive species, the controller deactivating the cold atmospheric jet after the sufficient time; and
a treatment device distinct from the plasma device operable to apply a reactive treatment to the sensitized cells in addition to the reactive species generated from the plasma jet after the cells are sensitized by the cold atmospheric plasma jet and the cold atmospheric plasma jet is deactivated.