US 12,383,670 B2
Instruments and methods for loading cells into implantable devices
Chad Green, San Diego, CA (US); Laura Martinson, San Diego, CA (US); Erik Olson, San Diego, CA (US); Val Anthony Bellora, San Diego, CA (US); Leah Elliott, San Diego, CA (US); Richard Alexander Grant, San Diego, CA (US); Donald Koenig, San Diego, CA (US); and Giacomo Strollo, San Diego, CA (US)
Assigned to ViaCyte, Inc., San Diego, CA (US)
Filed by ViaCyte, Inc., San Diego, CA (US)
Filed on Mar. 22, 2023, as Appl. No. 18/188,304.
Application 17/551,536 is a division of application No. 16/912,227, filed on Jun. 25, 2020, granted, now 11,246,979, issued on Feb. 15, 2022.
Application 16/912,227 is a division of application No. 15/528,731, granted, now 10,722,644, issued on Jul. 28, 2020, previously published as PCT/US2014/060306, filed on Nov. 20, 2014.
Application 18/188,304 is a continuation of application No. 17/551,536, filed on Dec. 15, 2021, granted, now 11,642,455.
Prior Publication US 2023/0293812 A1, Sep. 21, 2023
Int. Cl. A61M 5/142 (2006.01); A61F 2/02 (2006.01); A61M 37/00 (2006.01); B65B 3/00 (2006.01); C12N 5/071 (2010.01)
CPC A61M 5/14276 (2013.01) [A61F 2/022 (2013.01); A61M 5/142 (2013.01); A61M 37/0069 (2013.01); B65B 3/003 (2013.01); A61M 2209/045 (2013.01); C12N 5/0676 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A cell loading system for transferring cells from a cell source to an implantable device, the loading system comprising:
a support for supporting the implantable device;
a dosing tube assembly comprising a dosing tube and a fluid reservoir tube fluidly connected to the dosing tube, wherein the dosing tube has an outlet end that is positionable in the cell source to draw cells from the cell source into the dosing tube assembly and then removed from the cell source and positioned in the implantable device to inject cells contained in the dosing tube assembly into the implantable device;
a syringe pump comprising a piston, a cylinder, and a motor configured to control displacement of the piston relative to the cylinder, wherein the syringe pump is fluidly connected to the fluid reservoir tube, wherein the syringe pump is operable to draw cells from the cell source into the dosing tube assembly under negative pressure when the outlet end of the dosing tube is in the cell source, and the syringe pump is further operable to pump cells contained in the dosing tube assembly into the implantable device under positive pressure when the outlet end of the dosing tube is in the implantable device;
wherein the fluid reservoir tube has a first end fluidly connected to the dosing tube, a second end fluidly connected to the syringe pump, and a portion between the first and second ends that is wound into a coil; and
a mounting surface, wherein the coil is supported on the mounting surface in a horizontal position.