US 12,383,570 B2
Methods of selectively modulating gastrointestinal microbial growth
Stephane Duval, Carspach (FR); John Michael Geremia, Watertown, MA (US); Lisa Ann Laprade, Dedham, MA (US); April Waguespack-Levy, Ankeny, IA (US); Estefania Perez Calvo, Rosenau (FR); Ghislain Schyns, Waltham, MA (US); Viviane Verlhac, Dietwiller (FR); and Joshua Thomas Claypool, Cambridge, MA (US)
Assigned to DSM IP Assets B.V., Heerlen (NL)
Filed by DSM IP Assets B.V., Heerlen (NL)
Filed on Jan. 23, 2024, as Appl. No. 18/420,540.
Application 18/420,540 is a continuation of application No. 17/292,132, granted, now 11,911,405, issued on Feb. 27, 2024, previously published as PCT/US2019/060488, filed on Nov. 8, 2019.
Claims priority of provisional application 62/757,439, filed on Nov. 8, 2018.
Claims priority of provisional application 62/757,438, filed on Nov. 8, 2018.
Prior Publication US 2024/0293437 A1, Sep. 5, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/702 (2006.01); A23K 20/163 (2016.01); A23K 50/30 (2016.01); A23K 50/75 (2016.01)
CPC A61K 31/702 (2013.01) [A23K 20/163 (2016.05); A23K 50/30 (2016.05); A23K 50/75 (2016.05)] 9 Claims
 
1. A method of modulating the growth of at least one bacterial species in the gastrointestinal tract of a bird, said method comprising: administering a nutritional composition comprising a base nutritional composition and a synthetic oligosaccharide preparation to a bird, wherein said synthetic oligosaccharide preparation comprises at least n fractions of oligosaccharides each having a distinct degree of polymerization selected from 1 to n (DP1 to DPn fractions), wherein n is an integer greater than 3; and wherein each of a DP1 and DP2 fraction independently comprises from about 0.5% to about 15% of anhydro-subunit containing oligosaccharides by relative abundance as determined by mass spectrometry, wherein a level of at least one bacterial species in a gastrointestinal sample from said bird is increased or decreased relative to a level of said at least one bacterial species in a gastrointestinal sample from said bird prior to said administering said nutritional composition to said bird, and wherein said at least one bacterial species is selected from the group consisting of Odoribacter splanchnicus, Bacteroides dorei, Barnesiella intestinthominis, Bacillus clarus, Butyricimonas faecalis, Oscillibacter spp., Campylobacter jejuni, Helicobacter pullorum, Campylobacter coli, and Escherichia coli.