US 12,383,492 B2
Coatings for biological interface on implants
Anthony D. Duong, Columbus, OH (US); and Erik W. Edwards, Gahanna, OH (US)
Assigned to BATTELLE MEMORIAL INSTITUTE, Columbus, OH (US)
Appl. No. 17/043,220
Filed by Battelle Memorial Institute, Columbus, OH (US)
PCT Filed Apr. 2, 2019, PCT No. PCT/US2019/025290
§ 371(c)(1), (2) Date Sep. 29, 2020,
PCT Pub. No. WO2019/195216, PCT Pub. Date Oct. 10, 2019.
Claims priority of provisional application 62/651,360, filed on Apr. 2, 2018.
Prior Publication US 2021/0007974 A1, Jan. 14, 2021
Int. Cl. A61K 9/00 (2006.01); A61K 31/437 (2006.01); A61K 31/573 (2006.01); A61K 35/16 (2015.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/30 (2006.01); A61L 27/34 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01)
CPC A61K 9/0024 (2013.01) [A61K 31/437 (2013.01); A61K 31/573 (2013.01); A61K 35/16 (2013.01); A61K 38/1825 (2013.01); A61K 38/1841 (2013.01); A61K 38/185 (2013.01); A61K 38/1875 (2013.01); A61K 38/1891 (2013.01); A61K 38/19 (2013.01); A61K 38/193 (2013.01); A61K 38/30 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of forming a coating having a surface with exposed features thereon, comprising:
forming a coating upon a substrate; the coating comprising a biocompatible controlled release polymer and at least one active component; and
depositing fibers onto an outermost surface of the coating to form the exposed features, wherein the features include micrometer scale features and nanometer scale features that rise above the outermost surface of the coating, and wherein the outermost surface is also exposed.