US 12,053,618 B2
Fill-finish assemblies and related methods
Justin Harris, Reseda, CA (US); Matthew Wayne Janke, Simi Valley, CA (US); Wael Mismar, Redondo Beach, CA (US); Jerome Olivas, Thousand Oaks, CA (US); Thomas Clark Pearson, Newbury Park, CA (US); Sudeshna Dutta Ray, Thousand Oaks, CA (US); Ryan M. Agard, Royersford, PA (US); Alexis Dechelette, Jenkintown, PA (US); Michael Gammelager, Silkeborg (DK); Mads Hansen, Silkeborg (DK); Valerio Mazzon, Padua (IT); Owen Ryan, Wicklow (IE); and Clive Smith, Wicklow (IE)
Assigned to AMGEN INC., Thousand Oaks, CA (US)
Appl. No. 16/761,149
Filed by AMGEN INC., Thousand Oaks, CA (US)
PCT Filed Nov. 6, 2018, PCT No. PCT/US2018/059382
§ 371(c)(1), (2) Date May 1, 2020,
PCT Pub. No. WO2019/090303, PCT Pub. Date May 9, 2019.
Claims priority of provisional application 62/582,080, filed on Nov. 6, 2017.
Prior Publication US 2020/0338271 A1, Oct. 29, 2020
Int. Cl. A61M 5/28 (2006.01); A61M 5/178 (2006.01); A61M 5/24 (2006.01); A61M 5/31 (2006.01)
CPC A61M 5/28 (2013.01) [A61M 5/1782 (2013.01); A61M 5/24 (2013.01); A61M 5/3134 (2013.01); A61M 2005/2488 (2013.01); A61M 2005/3115 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A fill-finish assembly comprising:
a container;
an insertion mechanism including a delivery member and an insertion mechanism housing, the insertion mechanism being configured to move the delivery member from a retracted position wherein the delivery member is withdrawn inside the insertion mechanism housing to a deployed position wherein at least a portion of the delivery member extends outside of the insertion mechanism housing;
a fluid pathway connection assembly disposed between the container and the insertion mechanism, the fluid pathway connection assembly being selectively activatable to establish fluid communication between the container and the delivery member;
a carrier having a hollow interior containing at least a portion of each of the container, the insertion mechanism, and the fluid pathway connection assembly, the carrier being configured to hold the container, the insertion mechanism, and the fluid pathway connection assembly in alignment with each other to limit axial and rotational movement of the container, the insertion mechanism, and the fluid pathway connection assembly relative to each other; and
a protrusion extending inwardly from an inner circumferential surface of the carrier and directly engaging a distally facing end surface of the insertion mechanism to limit axial movement of the insertion mechanism relative to the carrier.