US 12,380,980 B1
Systems and methods for precision or personal pharmaceutical dosing
Dustin A. Heldman, Shaker Heights, OH (US); Brian Kolkowski, Leroy, OH (US); and Mark Pennington, Medina, OH (US)
Assigned to Great Lakes NeuroTechnologies Inc., Cleveland, OH (US)
Filed by Great Lakes NeuroTechnologies Inc., Cleveland, OH (US)
Filed on May 20, 2022, as Appl. No. 17/749,265.
Application 17/749,265 is a continuation of application No. 16/039,581, filed on Jul. 19, 2018, granted, now 11,367,519.
Int. Cl. A61M 5/142 (2006.01); A61B 5/00 (2006.01); A61B 5/11 (2006.01); A61M 5/172 (2006.01); G16H 20/17 (2018.01)
CPC G16H 20/17 (2018.01) [A61B 5/11 (2013.01); A61B 5/4839 (2013.01); A61B 5/486 (2013.01); A61B 5/7246 (2013.01); A61B 5/7275 (2013.01); A61M 5/142 (2013.01); A61M 5/1723 (2013.01); A61M 2205/3303 (2013.01); A61M 2205/505 (2013.01); A61M 2230/63 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A precision or personal drug or medication dosing system comprising:
at least one movement sensor adapted to acquire movement data or the movement data being derived from at least one physiological sensor, the movement data related to a subject's external body motion;
a diary interface adapted to allow the subject or a caregiver to enter personal data including at least perceived symptom data and medication information, the perceived symptom data being based on perception of the subject;
at least one database comprising historical data comprising;
historical movement data collected using at least one historical movement sensor or a historical physiological sensor corresponding to historical movement of the subject and/or others subjects,
historical personal data collected from historical diary interfaces and being collected from the subject or the other subjects,
treatment parameters for the subject and/or the other subjects corresponding to the historical movement data and the historical personal data; and
at least one processor adapted to correlate the subject's movement data and the personal data with the historical data on the database to generate a clinician report adapted to present the movement data, the personal data, and data related to and derived from the movement data, and the personal data to a clinician, the processor further adapted to predict when a drug or medication should be administered to prevent an increase in symptom severity based at least in part a correlation between current data (comprising the movement data and the personal data) and the historical data, and to provide a recommended drug or medication regimen comprising the drug, a drug dosage, and/or instructions for administration of the drug and/or the drug dosage to a clinician for review; and
a treatment algorithm comprised in the at least one processor or an additional processor adapted to provide the recommended drug or medication regimen based on a constraint of minimizing the drug dosage by providing one or more of the drug dosages at a time adapted to prevent an increase quantification of at least one symptom,
wherein the recommended drug or medication regimen is adapted to provide a desired drug profile in a bloodstream of the first subject, the system is further adapted to recommend or provide a new or additional drug dose based on the clinician report and/or the prediction of when the drug or medication should be administered in order to prevent an onset or recurrence of the at least one symptom, and the desired drug profile adapted to be maintained within ±75% of a blood concentration or a desired threshold value corresponding to the desired drug profile in the bloodstream of the subject.