US 12,379,312 B2
Systems and methods for imaging and characterizing objects including the eye using non-uniform or speckle illumination patterns
Rafael Piestun, Boulder, CO (US); Kristina Irsch, Paris (FR); Simon Labouesse, Boulder, CO (US); and Sylvain Gigan, Paris (FR)
Assigned to The Regents of the University of Colorado, Denver, CO (US); and Sorbonne Université, Paris (FR)
Appl. No. 17/765,364
Filed by The Regents of the University of Colorado, Denver, CO (US); and Sorbonne Université, Paris (FR)
PCT Filed Sep. 30, 2020, PCT No. PCT/US2020/053656
§ 371(c)(1), (2) Date Mar. 30, 2022,
PCT Pub. No. WO2021/067515, PCT Pub. Date Apr. 8, 2021.
Claims priority of provisional application 62/908,151, filed on Sep. 30, 2019.
Prior Publication US 2022/0390369 A1, Dec. 8, 2022
Int. Cl. G01N 21/47 (2006.01); A61B 5/00 (2006.01); G01N 21/64 (2006.01)
CPC G01N 21/47 (2013.01) [A61B 5/0084 (2013.01); G01N 21/6456 (2013.01); A61B 5/0066 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A system comprising:
at least one light source to generate two or more non-uniform illumination patterns on an object, wherein the at least one light source is configured to illuminate at least a portion of the object with:
light of at least two colors; and
at least two different speckle patterns comprising a first speckle pattern of a first color of light and at least a second speckle pattern of at least a second color of light, wherein the two or more non-uniform illumination patterns comprise the two different speckle patterns;
a detector array to extract data representing backscattering from the object; and
a processing unit configured to:
receive the data representing backscattering from the object; and
generate one or more images of at least a portion of the object.