US 12,378,599 B2
Probe set for analyzing a DNA sample and method for using the same
Carl Oscar Fredrik Dahl, Sigtuna (SE); Olof John Ericsson, Uppsala (SE); Filip Karlsson, Solna (SE); and Fredrik Roos, Stockholm (SE)
Assigned to VANADIS DIAGNOSTICS, Sollentuna (SE)
Filed by Vanadis Diagnostics, Sollentuna (SE)
Filed on Jan. 20, 2023, as Appl. No. 18/099,913.
Application 18/099,913 is a continuation of application No. 17/039,490, filed on Sep. 30, 2020, granted, now 11,591,639.
Application 17/039,490 is a continuation of application No. 16/679,098, filed on Nov. 8, 2019, granted, now 10,822,640, issued on Nov. 3, 2020.
Application 16/679,098 is a continuation of application No. 15/268,322, filed on Sep. 16, 2016, granted, now 10,508,300, issued on Dec. 17, 2019.
Claims priority of provisional application 62/220,746, filed on Sep. 18, 2015.
Prior Publication US 2023/0159991 A1, May 25, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/11 (2006.01); C12Q 1/682 (2018.01); C12Q 1/6858 (2018.01)
CPC C12Q 1/682 (2013.01) [C12Q 1/6858 (2013.01)] 12 Claims
 
1. A ligatable nucleic acid complex of formula X-A-B-Z or X-B-A-Z, wherein, in the complex:
sequences A and B are in separate molecules,
sequences X, A, B and Z are ligatably adjacent to one another and held in position by a splint oligonucleotide,
sequence A is a target fragment of a genome,
sequence B identifies the locus from which the adjacent sequence A is derived but is not from the locus, and
the splint oligonucleotide is of formula X′-A′-B′-Z′ or X′-B′-A′-Z′.