US 12,378,547 B2
Synthetic genome
Julius Fredens, Swindon (GB); Kaihang Wang, Swindon (GB); Daniel De La Torre, Swindon (GB); Louise F. H. Funke, Swindon (GB); Wesley E. Robertson, Swindon (GB); and Jason W. Chin, Swindon (GB)
Assigned to United Kingdom Research and Innovation, Swindon (GB); and Scarab Genomics, LLC, Madison, WI (US)
Filed by United Kingdom Research and Innovation, Swindon (GB); and Scarab Genomics, LLC, Madison, WI (US)
Filed on Oct. 24, 2023, as Appl. No. 18/493,307.
Application 18/493,307 is a continuation of application No. 18/321,475, filed on May 22, 2023, abandoned.
Application 18/321,475 is a continuation of application No. 17/610,974, previously published as PCT/EP2020/063445, filed on May 14, 2020.
Prior Publication US 2024/0132874 A1, Apr. 25, 2024
Prior Publication US 2024/0229013 A9, Jul. 11, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/10 (2006.01); C12N 1/20 (2006.01); C12N 15/90 (2006.01)
CPC C12N 15/1031 (2013.01) [C12N 1/205 (2021.05); C12N 15/902 (2013.01)] 6 Claims
 
1. A synthetic E. coli genome, wherein 90% or more of occurrences of an amber stop codon (TAG) are replaced with TAA and 90% or more of occurrences of a serine codon are replaced with a synonymous codon.