US 12,378,312 B2
Polynucleotides encoding human beta klotho antibodies or binding fragments thereof and methods of use thereof
Kalyani Mondal, San Mateo, CA (US); Betty Chan Li, Millbrae, CA (US); Yu Chen, Foster City, CA (US); Taruna Arora, Palo Alto, CA (US); Hugo Matern, San Mateo, CA (US); and Wenyan Shen, Redwood City, CA (US)
Assigned to NGM Biopharmaceuticals, Inc., South San Francisco, CA (US)
Filed by NGM Biopharmaceuticals, Inc., South San Francisco, CA (US)
Filed on Jan. 12, 2023, as Appl. No. 18/153,643.
Application 18/153,643 is a continuation of application No. 16/928,862, filed on Jul. 14, 2020, granted, now 11,596,676.
Application 16/928,862 is a continuation of application No. 16/103,613, filed on Aug. 14, 2018, granted, now 10,744,191, issued on Aug. 18, 2020.
Application 16/103,613 is a continuation of application No. 15/659,177, filed on Jul. 25, 2017, granted, now 10,093,735, issued on Oct. 9, 2018.
Application 15/659,177 is a continuation of application No. 14/604,592, filed on Jan. 23, 2015, granted, now 9,738,716, issued on Aug. 22, 2017.
Claims priority of provisional application 61/931,531, filed on Jan. 24, 2014.
Prior Publication US 2023/0256070 A1, Aug. 17, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/13 (2006.01); A61K 39/00 (2006.01); C07K 16/28 (2006.01); G01N 33/66 (2006.01)
CPC C07K 16/28 (2013.01) [A61K 39/001154 (2018.08); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/75 (2013.01); G01N 33/66 (2013.01)] 23 Claims
 
1. An isolated polynucleotide or polynucleotides encoding an antibody or binding fragment thereof that binds human beta klotho, wherein the antibody or binding fragment thereof comprises
a heavy chain variable region (VH) comprising a VH complementarity determining region (CDR)1, a VH CDR2, and a VH CDR3 from the amino acid sequence of SEQ ID NO:271; and
a light chain variable region (VL) comprising a VL CDR1, a VL CDR2, and a VL CDR3 from the amino acid sequence of SEQ ID NO:276.