US 12,378,298 B2
T cell receptor
Hans Stauss, London (GB); Sharyn Thomas, London (GB); Ben Willcox, Birmingham (GB); and Fiyaz Mohammed, Birmingham (GB)
Assigned to UCL BUSENESS LTD, London (GB)
Filed by UCL Business Ltd, London (GB)
Filed on Jun. 24, 2021, as Appl. No. 17/357,780.
Application 17/357,780 is a division of application No. 15/568,440, abandoned, previously published as PCT/GB2016/051084, filed on Apr. 20, 2016.
Claims priority of application No. 1506642 (GB), filed on Apr. 20, 2015.
Prior Publication US 2021/0395331 A1, Dec. 23, 2021
Int. Cl. C07K 14/725 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/7051 (2013.01) [A61K 38/00 (2013.01)] 3 Claims
 
1. A method for increasing the cell surface expression of a TCR, comprising
(i) providing a TCR α chain and β chain sequence;
(ii) determining an amino acid residue of the TCR α chain and β chain at positions 96 of the α chain and 10 of the β chain; and
(iii) altering the amino acid residue at the positions listed in step (ii) to L96 of the α chain and Y10 of the β chain.