	US 12,378,280 B2
	Deoxynucleic guanidines (DNG)-modified oligonucleotides and methods of synthesizing deoxynucleic guanidine strands
Chad A. Mirkin, Wilmette, IL (US); Kacper Skakuj, Durham, NC (US); and Katherine E. Bujold, Magog (CA)
Assigned to NORTHWESTERN UNIVERSITY, Evanston, IL (US)
Filed by NORTHWESTERN UNIVERSITY, Evanston, IL (US)
Filed on Jun. 19, 2020, as Appl. No. 16/906,619.
Claims priority of provisional application 62/870,639, filed on Jul. 3, 2019.
Claims priority of provisional application 62/864,682, filed on Jun. 21, 2019.
Claims priority of provisional application 62/864,720, filed on Jun. 21, 2019.
Prior Publication US 2020/0399304 A1, Dec. 24, 2020
Int. Cl. C07H 21/02 (2006.01); A61K 9/51 (2006.01); A61K 31/7125 (2006.01); A61K 47/02 (2006.01); C07H 21/04 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/85 (2006.01)

CPC C07H 21/04 (2013.01) [A61K 9/5115 (2013.01); A61K 31/7125 (2013.01); A61K 47/02 (2013.01); C12N 15/11 (2013.01); C12N 15/113 (2013.01); C12N 15/85 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01)]

15 Claims

1. A spherical nucleic acid (SNA) comprising a nanoparticle functionalized with an oligonucleotide comprising at least one deoxynucleic guanidine modification (DNG) located at an outer surface of the SNA, and wherein the SNA exhibits increased cellular uptake compared to an unmodified SNA.