US 12,378,211 B2
Carbonic anhydrase inhibitors and antibiotics against multidrug resistant bacteria
Daniel P Flaherty, West Lafayette, IN (US); Mohamed Seleem, West Lafayette, IN (US); Jatinder Kaur, Edmonton (CA); and Xufeng Cao, West Lafayette, IN (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Appl. No. 17/415,899
Filed by Purdue Research Foundation, West Lafayette, IN (US)
PCT Filed Dec. 18, 2019, PCT No. PCT/US2019/067020
§ 371(c)(1), (2) Date Jun. 18, 2021,
PCT Pub. No. WO2020/131980, PCT Pub. Date Jun. 25, 2020.
Claims priority of provisional application 62/781,824, filed on Dec. 19, 2018.
Prior Publication US 2022/0056001 A1, Feb. 24, 2022
Int. Cl. C07D 285/135 (2006.01); A61P 31/04 (2006.01)
CPC C07D 285/135 (2013.01) [A61P 31/04 (2018.01)] 12 Claims
 
1. A method for treating a patient with a bacterial infection comprising the step of administrating a therapeutically effective amount of a carbonic anhydrase inhibitor having the formula (I), or a pharmaceutically acceptable salt thereof, together with one or more diluents, excipients or carriers, to the patient in need of treatment for said infection,

OG Complex Work Unit Chemistry
wherein
R1 is

OG Complex Work Unit Chemistry
 or
an alkynyl, each of which is optionally substituted.
 
2. A method for decolonizing a patient with a bacterial infection comprising the step of administrating a therapeutically effective amount of a carbonic anhydrase inhibitor having the formula (I), or a pharmaceutically acceptable salt thereof, together with one or more diluents, excipients or carriers, to the patient in need of treatment,

OG Complex Work Unit Chemistry
wherein
R1 is

OG Complex Work Unit Chemistry
 or
an alkynyl, each of which is optionally substituted.
 
7. A compound having the formula (I)

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein
R1 is

OG Complex Work Unit Chemistry
 or
an alkynyl, each of which is optionally substituted.