US 12,378,206 B2
Heteroaryl butanoic acid derivatives
Birgit Bollbuck, Munich (DE); Christian Markert, Riehen (CH); Wolfgang Miltz, Allschwil (CH); and Till Roehn, Zurich (CH)
Assigned to Novartis AG, Basel (CH)
Filed by NOVARTIS AG, Basel (CH)
Filed on Aug. 17, 2022, as Appl. No. 17/820,348.
Application 15/895,224 is a division of application No. 15/104,729, granted, now 9,981,926, issued on May 29, 2018, previously published as PCT/IB2014/067086, filed on Dec. 18, 2014.
Application 17/820,348 is a continuation of application No. 15/895,224, filed on Feb. 13, 2018, granted, now 11,453,651.
Claims priority of application No. 13199138 (EP), filed on Dec. 20, 2013; and application No. 14181155 (EP), filed on Aug. 15, 2014.
Prior Publication US 2022/0411385 A1, Dec. 29, 2022
Int. Cl. C07D 401/12 (2006.01); A61K 31/41 (2006.01); A61K 31/415 (2006.01); A61K 31/422 (2006.01); A61K 31/4245 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 45/06 (2006.01); C07D 231/12 (2006.01); C07D 257/04 (2006.01); C07D 271/10 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01)
CPC C07D 257/04 (2013.01) [A61K 31/41 (2013.01); A61K 31/415 (2013.01); A61K 31/422 (2013.01); A61K 31/4245 (2013.01); A61K 31/428 (2013.01); A61K 31/4439 (2013.01); A61K 45/06 (2013.01); C07D 231/12 (2013.01); C07D 271/10 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01)] 1 Claim
 
1. A method of preparing (S)-3-amino-4-(5-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenyl)-2H-tetrazol-2-yl)butanoic acid or a pharmaceutically acceptable salt thereof:

OG Complex Work Unit Chemistry
said method comprising the steps of
a) reacting a compound of Formula (4c) with a compound of Formula (2a) to form a compound of Formula (5aa)
and
b) converting the compound of Formula (5aa) to S)-3-amino-4-(5-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenyl)-2H-tetrazol-2-yl)butanoic acid.