US 12,377,409 B2
Inorganic porous carrier, and production method for nucleic acid using same
Takashi Arimura, Tsukuba (JP); Masaki Kitahara, Chuo-ku (JP); Takeshi Yoshioka, Osaka (JP); and Takashi Hara, Osaka (JP)
Assigned to SUMITOMO CHEMICAL COMPANY, LIMITED, Chuo-ku (JP)
Appl. No. 17/599,700
Filed by SUMITOMO CHEMICAL COMPANY, LIMITED, Chuo-ku (JP)
PCT Filed Feb. 28, 2020, PCT No. PCT/JP2020/008323
§ 371(c)(1), (2) Date Sep. 29, 2021,
PCT Pub. No. WO2020/202952, PCT Pub. Date Oct. 8, 2020.
Claims priority of application No. 2019-067996 (JP), filed on Mar. 29, 2019.
Prior Publication US 2022/0193648 A1, Jun. 23, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. B01J 31/26 (2006.01); C07H 1/00 (2006.01); C07H 21/00 (2006.01)
CPC B01J 31/26 (2013.01) [C07H 1/00 (2013.01); C07H 21/00 (2013.01)] 18 Claims
 
1. An inorganic porous carrier, comprising:
a linker of formula (1); and
an inorganic porous substance connected to the linker,
wherein the inorganic porous substance has a most frequent value of pore diameter, which is a mode diameter, ranging from 0.04 μm to 1 μm in a pore distribution as measured by mercury intrusion method, and the inorganic porous substance has a density of voids from 12 voids/μm2 to 30 voids/μm2, the voids having an opening area of 0.0025 m2 or more as obtained by image analysis of a surface of the inorganic porous substance,

OG Complex Work Unit Chemistry
wherein,
a bond marked with * is a linkage to an oxygen atom of a silanol group in the inorganic porous substance;
n is an integer of 1, 2 or 3;
R is independently of each other an alkyl group including 3 to 10 carbon atoms which may optionally have a substituent selected from the group consisting of an alkoxy group and a fluorine atom; a phenyl group which may optionally have a substituent selected from the group consisting of an alkyl group, an alkoxy group, and a fluorine atom; a hydroxyl group; or an alkoxy group including 1 to 4 carbon atom; and
L is a single bond; an alkylene group of 1 to 20 carbon atoms; or an alkylene group including 2 to 20 carbon atoms which includes —CH2-Q-CH2— group wherein Q is selected from the group consisting of —O—, —NH—, —NH—CO— and —NH—CO—NH—, Q is inserted into at least one of —CH2—CH2— group constituting the alkylene group, and a carbon atom of a methylene group bonded to Q is not bonded to another group Q.