US 12,377,185 B2
Sealant dressing with protected reactive components
Thomas Weindl, Somerville, NJ (US); Xuejun Jay Liu, Somerville, NJ (US); Gerard Llanos, Somerville, NJ (US); Yi-Lan Allen Wang, Hillsborough, NJ (US); and Wilai Kosol, Somerset, NJ (US)
Assigned to Ethicon, Inc., Raritan, NJ (US)
Filed by Ethicon, Inc., Somerville, NJ (US)
Filed on Aug. 31, 2020, as Appl. No. 17/007,712.
Prior Publication US 2022/0062492 A1, Mar. 3, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 15/22 (2006.01); A61L 15/18 (2006.01); A61L 15/32 (2006.01); A61L 15/64 (2006.01); B32B 27/08 (2006.01)
CPC A61L 15/225 (2013.01) [A61L 15/18 (2013.01); A61L 15/325 (2013.01); A61L 15/64 (2013.01); B32B 27/08 (2013.01); A61L 2300/608 (2013.01); A61L 2400/16 (2013.01); B32B 2250/03 (2013.01); B32B 2250/24 (2013.01); B32B 2307/7163 (2013.01); B32B 2535/00 (2013.01)] 4 Claims
OG exemplary drawing
 
1. A multi-layered wound dressing consisting of:
a. a bi-layer carrier substrate consisting of a layer of oxidized cellulose joined to a layer of fibers composed of a copolymer made from 90% glycolide and 10% L-lactide;
b. a coating consisting of stacked spray-coated layers of
a layer of alkaline buffer immediately on the carrier substrate,
a layer of PEG-N-hydroxysuccinimide, and
a layer of protected PEG-amine end-capped with a plurality of hydrohalide protective leaving groups between the layer of alkaline buffer and the layer of PEG-N-hydroxysuccinimide,
wherein the alkaline buffer is disodium tetraborate, bis-tris methane (Bis-Tris), or 2-(N-morpholino) ethanesulfonic acid (MES).