	US 12,377,124 B2
	Topical compositions comprising viable probiotic bacteria
Mogens Dolmer, Hoersholm (DK); Mette Ingemann, Hoersholm (DK); and Mette Winning, Hoersholm (DK)
Assigned to Chr. Hansen A/S, Hoersholm (DK)
Appl. No. 17/257,429
Filed by Chr. Hansen A/S, Hoersholm (DK)
PCT Filed Jul. 3, 2019, PCT No. PCT/EP2019/067888 § 371(c)(1), (2) Date Dec. 31, 2020, PCT Pub. No. WO2020/007931, PCT Pub. Date Jan. 9, 2020.
Claims priority of application No. 18181691 (EP), filed on Jul. 4, 2018.
Prior Publication US 2021/0220416 A1, Jul. 22, 2021
Int. Cl. A61K 35/747 (2015.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 35/745 (2015.01); A61K 45/06 (2006.01); A61K 47/06 (2006.01); A61K 47/14 (2017.01); A61K 47/44 (2017.01)

CPC A61K 35/747 (2013.01) [A61K 9/0014 (2013.01); A61K 9/16 (2013.01); A61K 35/745 (2013.01); A61K 45/06 (2013.01); A61K 47/06 (2013.01); A61K 47/14 (2013.01); A61K 47/44 (2013.01)]

18 Claims

1. A topical probiotic composition, comprising:

viable probiotic bacteria of at least one probiotic bacterial strain selected from the genus Lactobacillus and Bifidobacterium, and

at least one hydrophobic compound selected from anionic emulsifying wax, candelilla wax, camauba wax, cetyl palmitate, cocoa butter, gum arabic, hard fat, microcrystalline wax, nonionic emulsifying wax, paraffin, shea butter, synthetic beeswax, white wax, xanthan gum, sunflower wax, monoglycerides, diglycerides, glyceryl behenate, glyceryl palmitostearate, glyceryl stearate, and caprylic, capric, myristic, and stearic triglycerides, and oils and waxes that are fluid at room temperature selected from ethyl oleate, evening primrose oil, grapeseed oil, hydrogenated vegetable oil, isopropyl isostearate, isopropyl myristate, isopropyl palmitate, jojoba oil, liquid lanolin, macademia oil, medium chain triglycerides, olive oil, paraffin oil, mineral oil, pomegranate oil, rapeseed oil, rice bran oil, rosehip oil, safflower oil, sesame oil, shea nut butter, soybean oil, sunflower oil, sweet almond oil, trimyristin, tripalmitin, tristearin, and avocado oil,

wherein said viable probiotic bacteria have a water activity of no more than 0.30 and a diameter of no more than 300 μm;

wherein, after storage for 1 day at 30° C. and 75% RH, the topical probiotic composition comprises at least 10⁶CFU/g of said viable probiotic bacteria; and

wherein the topical probiotic composition is formulated as a cream, drop, foam, gel, lotion, ointment, paste, poultice, salve, spray, thickened formulation, or unguent.