US 12,377,110 B2
Fospropofol methods and compositions
Steven L. Krill, San Clemente, CA (US); Feng-Jing Chen, Irvine, CA (US); Michael A. Rogawski, Sacramento, CA (US); Edward Brendan Magrab, Far Hills, NJ (US); and Allen H. Heller, Woodbridge, CT (US)
Assigned to EPALEX CORPORATION, Mountain View, CA (US)
Filed by Epalex Corporation, Mountain View, CA (US)
Filed on Feb. 15, 2023, as Appl. No. 18/169,296.
Application 17/465,966 is a division of application No. 17/217,656, filed on Mar. 30, 2021, granted, now 11,207,334, issued on Dec. 28, 2021.
Application 18/169,296 is a continuation of application No. 17/686,738, filed on Mar. 4, 2022, granted, now 11,628,178.
Application 17/686,738 is a continuation of application No. 17/562,605, filed on Dec. 27, 2021, abandoned.
Application 17/562,605 is a continuation in part of application No. 17/465,966, filed on Sep. 3, 2021.
Application 17/562,605 is a continuation in part of application No. 17/466,016, filed on Sep. 3, 2021, granted, now 11,439,653, issued on Sep. 13, 2022.
Application 17/562,605 is a continuation in part of application No. 17/387,059, filed on Jul. 28, 2021, granted, now 11,478,490, issued on Oct. 25, 2022.
Application 17/387,059 is a continuation in part of application No. 17/217,656, filed on Mar. 30, 2021, granted, now 11,207,334, issued on Dec. 28, 2021.
Application 17/466,016 is a continuation of application No. 17/217,656, filed on Mar. 30, 2021, granted, now 11,207,334, issued on Dec. 28, 2021.
Application 17/562,605 is a continuation in part of application No. 17/168,365, filed on Feb. 5, 2021, granted, now 11,547,714, issued on Jan. 10, 2023.
Application 17/562,605 is a continuation in part of application No. 17/066,957, filed on Oct. 9, 2020, abandoned.
Application 17/562,605 is a continuation in part of application No. 16/831,035, filed on Mar. 26, 2020, abandoned.
Claims priority of provisional application 62/970,324, filed on Feb. 5, 2020.
Claims priority of provisional application 62/914,051, filed on Oct. 11, 2019.
Claims priority of provisional application 62/824,182, filed on Mar. 26, 2019.
Prior Publication US 2023/0277567 A1, Sep. 7, 2023
Int. Cl. A61K 31/661 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 47/12 (2006.01)
CPC A61K 31/661 (2013.01) [A61K 9/0053 (2013.01); A61K 9/2013 (2013.01); A61K 47/12 (2013.01)] 32 Claims
 
1. A method of treating migraine in a patient in need thereof, the method comprising orally administering a propofol prodrug, a pharmaceutically acceptable salt of a propofol prodrug, or mixtures thereof, to the patient in one or more doses, wherein the administration results in a Cmax of propofol of at least 50-500 ng/mL, wherein following the administration the patient is headache free, has experienced a reduction in headache pain, or is no longer experiencing a most bothersome symptom, and
wherein the propofol prodrug is:
sodium 2-(2-(2,6-diisopropylphenoxy)-2-oxoethoxy)acetate;
(Azepan-1-ylcarbamoylmethyl)carbamic acid 2,6-diisopropylphenyl ester hydrochloride; (E)-3-(2,6-diisopropylphenoxy)acrylic acid;
(O-[2-carboxyethyl]-propofol), (S)-2-amino-3-(2,6-diisopropylphenoxycarbonyloxy)-propanoic acid;
(S)-2-amino-3-(2,6-diisopropylphenoxycarbonyloxy)-propanoic acid mesylate salt; (S)-2-amino-3-(2, 6-diisopropylphenoxycarbonyloxy)-propanoic acid hydrochloride;
{1-[3-(2, 6-diisopropylphenoxy)-3-oxo-2(R)-fluoro-1-propyl]}phosphate monoesterdipotassium salt;
{1-[4-(2,6-diisopropylphenoxy)-4-oxo-2(R)-trifluoromethyl-1-butyl]}phosphate monoester dilithium salt;
{1-[4-(2,6-diisopropylphenoxy)-4-oxo-3-(R)-3-trifluoromethyl-1-butyl]}phosphate monoester dilithium salt; {1-[4-(2,6-diisopropylphenoxy)-4-oxo-3-(R,S)-3-fluoro-1-butyl]} phosphate monoesterdipotassium salt;
{1-[4-(2,6-diisopropylphenoxy)-4-oxo-3-(S)-3-fluoro-1-butyl]} phosphate monoester disodium salt;
{1-[6-(2,6-diisopropylphenoxy)-6-oxo-5-(S)-difluoromethyl-1-hexyl]} phosphate di arginine salt;
1-((((2,6-diisopropyl phenoxy)carbonyl) oxy)methyl)-3-(dimethylcarbamoyl) pyridinium iodide;
1-((((2,6-diisopropylphenoxy)carbonyl) oxy)methyl)-3-(hydroxycarbamoyl) pyridin-1-ium iodide;
1-((((2,6-diisopropylphenoxy)carbonyl) oxy)methyl)-3-(methoxycarbonyl)pyridin-1-ium iodide;
1-((((2,6-diisopropylphenoxy)carbonyl) oxy)methyl)-3-(methoxycarbonyl)pyridin-1-ium methanesulfonate;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-3-(methylcarbamoyl)pyridin-1-ium tetrafluoroborate;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-3-(methylcarbamoyl)pyridin-1-ium nitrate;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-3-(methylcarbamoyl)pyridin-1-ium chloride;
1-((((2,6-diisopropylphenoxy)carbonyl) oxy)methyl)-4-formyl-3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-1-ium iodide;
1-(((2,6-diisopropylphenoxy)carbonyl)oxy)N-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-N,N-dimethyl-methanaminiumiodide;
1-(((2,6-diisopropylphenoxy)carbonyloxy)methyl)-3-(dimethylcarbamoyl)pyridinium mesylate;
1-(((2,6-diisopropylphenoxy)carbonyloxy) methyl)-3-(methylcarbamoyl)pyridinium mesylate;
1-(((2,6-diisopropylphenoxy)carbonyloxy)methyl)-3-(methylcarbamoyl)pyridiniumiodide;
1-((2′,6′-diisopropylphenoxy)carbonylamino)ethyl-2,3,4,6-tetra-O-acetyl-β-D-glucopyrano side;
1-((2′,6′diisopropylphenoxy) carbonylamino)ethyl-β-D-glucopyranoside;
1-((2′,6′diisopropylphenoxy)carbonyloxy)ethyl-2,3,4,6-tetra-O-acetyl-13-D-glucopyranoside;
1-((2′,6′diisopropylphenoxy)carbonyloxy)ethyl-2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside;
1-((2′,6′diisopropylphenoxy)carbonyloxy)ethyl-hepta-O-acetyl-13-D-maltose;
1-((2′,6′diisopropylphenoxy)carbonyloxy)ethyl-α-D-glucopyranoside;
1-((2′,6′-diisopropylphenoxy)carbonyloxy)ethyl-β-D-maltose;
1-((2′,6′diisopropylphenoxy)carbonyloxy)ethyl-β-n-glucopyranoside;
1-((2′,6′diisopropylphenoxy)carbonyloxy)propyl-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside;
1-((2′,6′-diisopropylphenoxy)carbonyloxy)propyl-2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside;
1-((2′,6′-diisopropylphenoxy)carbonyloxy)propyl-hepta-O-acetyl-β-D-maltose;
1-((2′,6′-diisopropylphenoxy)carbonyloxy)propyl-α-D-glucopyranoside;
1-((2′,6′diisopropylphenoxy)carbonyloxy)propyl-β-D-glucopyranoside;
1-((2′,6′diisopropylphenoxy)carbonyloxy)propyl-β-D-maltose;
1-Amino-2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethane;
2-[2,6-(Diisopropyl)phenoxycarbonyloxy]ethyl (2S)-2-amino-3-hydroxypropionamide;
2-(((2,6-diisopropylphenoxy)carbonyl) oxy)-N((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-N,N-dimethylethan-1-aminiumiodide;
2-(((2,6-diisopropylphenoxy)carbonyl)oxy)-N,N,N-trimethylethan-1-aminium iodide;
2-(((2,6-diisopropyl phenoxy)carbonyl)oxy)-N,N,N-trimethyl ethan-1-aminium methanesulfonate;
2-(2,6-diisopropyl phenoxy)-2-hydroxyethyl phosphate;
2-(2,6-diisopropylphenoxy)-3,4,5-trihydroxy tetrahydropyran-6-yl, dihydrogen phosphate;
2-(2,6-diisopropylphenxoy)-3,4,5-trihydroxytetrahydropyran-6-yl dihydrogen phosphate arginine;
2,6-(diisopropyl)phenyl 1-[((2S)-2-amino-(3R)-3-hydroxybutyryl)aminomethyl]-1-cyclohexane acetate;
2,6-(diisopropyl)phenyl 1-[((2S)-2-amino-3-hydroxypropionyl)aminomethyl]-1-cyclohexane acetate;
2,6-(diisopropyl)phenyl 1-[((2S)-2-amino-3-methylbutyryl)aminomethyl]-1-cyclohexane acetate;
2,6-(diisopropyl)phenyl 4-[(2S)-2,3-diaminopropionylamino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2,6-diaminohexanoylamino]-3,3-dimethylbutanoate;
2,6-(Diisopropyl)phenyl 4-[(2S)-2-amino-(3R)-3-hydroxylbutyryl]aminobutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-(3R)-3-hydroxybutyryl]amino-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-(3R)-3-hydroxylbutyryl]aminobutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-(4-hydroxyphenyl)propionylamino]-3,3-dimethylbutanoate;
2,6-(Diisopropyl)phenyl 4-[(2S)-2-amino-(indol-3-yl)propionylamino]-3,3-dimethylbutanoate;
2,6-(Diisopropyl)phenyl 4-[(2S)-2-amino-3-carbamoylpropionylamino]butanoate;
2,6-(Diisopropyl)phenyl 4-[(2S)-2-amino-3-hydroxypropionylamino]butanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-3-carbamoylpropionylamino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-3-carbamoylpropionylamino]butanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-3-carboxypropionylamino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-3-hydroxypropionylamino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl4-[(2S)-2-amino-3-hydroxypropionylamino]butanoate;
2,6-(Diisopropyl)phenyl 4-[(2S)-2-amino-3-hydroxypropionylamino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-3-methylbutyrylamino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-3-methylbutyrylamino]butanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-4-carboxybutyrylamino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-amino-4-carboxylbutyrylamino]butanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-2-aminopropionylamino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl4-[(2S)-pyrrolidin-2-ylcarbonylamino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl 4-[(2S)-pyrrolidin-2-ylcarbonylamino]butanoate;
2,6-(Diisopropyl)phenyl 4-[(2S)-pyrrolidin-2-ylcarbonylaraino]-3,3-dimethylbutanoate;
2,6-(diisopropyl)phenyl 4-[aminomethylcarbonylamino]-3,3-dimethylbutanoate;
2,6-(Diisopropyl)phenyl 1-[((2S)-2-amino-(3R)-3-hydroxybutyryl)aminomethyl]-1-cyclohexane acetate;
2,6-(Diisopropyl)phenyl 1-[((2S)-2-amino-3-hydroxypropionyl)aminomethyl]1-cyclohexane acetate;
2,6-(Diisopropyl)phenyl 1-[((2S)-2-amino-3-methylbutyryl)aminomethyl]-1-cyclohexane acetate;
2,6-diisopropylphenyl 4-((2-(2-methylpyrazolidin-1-yl)ethyl)amino)-4-oxobutanoate;
2,6-diisopropylphenyl 4-((2-(4,5-dihydro-1H-pyrazol-1-yl)ethyl)amino)-4-oxobutanoate;
2,6-diisopropylphenyl 4-((2-(4-ethylpiperazin-1-yl)ethyl)amino)-4-oxobutanoate;
2,6-diisopropylphenyl 4-((2-(4-methylpiperazin-1-yl)ethyl)amino)-4-oxobutanoate; 2,6-diisopropylphenyl4-((2-morpholinoethyl)amino)-4-oxobutanoate;
2,6-Diisopropylphenyl 4-(2-(TertButoxycarbonylamino) Propanoyloxy)Butanoate;
2,6-Diisopropylphenyl4-(2-Aminoacetoxy) Butanoate Trifluoroacetic Acid Salt;
2,6-Diisopropylphenyl 4-(2-Aminopropanoyloxy)Butanoate Hydrochloride;
2,6-Diisopropyl phenyl 4-Hydroxybutanoate;
2,6-diisopropyl phenyl 4-oxo-4-((2-(piperazin-1-yl)ethyl)amino)butanoate;
2,6-diisopropyl phenyl 4-oxo-4-((2-(piperidin-1-yl)ethyl)amino)butanoate;
2,6-diisopropyl phenyl 4-oxo-4-((2-(pyrazolidin-1-yl)ethyl)amino)butanoate;
2,6-diisopropylphenyl 4-oxo-4-((2-(pyrrolidin-1-yl)ethyl)amino)butanoate;
2, 6-diisopropylphenyl 4-oxo-4-((2-thiomorpholinoethyl)amino)butanoate;
2-[2,6-(diisopropyl)phenoxycarbonylamino]ethyl (2S)-2-amino-3-carboxypropionamide;
2-[2,6-(diisopropyl)phenoxycarbonylamino]ethyl (2S)-2-amino-3-hydroxypropionamide;
2-[2,6-(diisopropyl)phenoxycarbonylamino]ethyl (2S)-2-amino-3-methylbutanoylamide;
2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethyl (2S)-2,6-diaminohexanoylamide;
2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethyl (2S)-2-amino-(4-hydroxyphenyl)propionamide;
2-[2,6-(Diisopropyl)phenoxycarbonyloxy]ethyl (2S)-2-amino(4-hydroxyphenyl)propionamide;
2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethyl (2S)-2-amino-3-carbamoylpropionate;
2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethyl (2S)-2-amino-3-carbamoylpropionamide;
2-[2,6-(Diisopropyl)phenoxycarbonyloxy]ethanol;
1-Amino-2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethane;
2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethyl (2S)-2-amino-3-hydroxypropionate;
2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethyl (2S)-2-amino-3-hydroxypropionamide;
2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethyl glycinamide;
2-amino-3-(2,6-diisopropylphenoxycarbonyloxy)-propanoic acid mesylate;
2-amino-3-methyl-3-(2,6-diisopropyl-phenoxycarbonyloxy)-propanoic acid;
3-(((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)carbamoyl)-1-methylpyridin-1-ium iodide;
3-((2,6-diisopropylphenoxy)carbonyl)-1-((((2,6-diisopropyl phenoxy)carbonyl)oxy) methyl)pyridin-1-ium methanesulfonate;
3-{[2-[2,6-Bis(isopropyl)phenoxycarbonyl]-benzoyl]amino}propanoic acid;
3-{[2-[2,6-Bis(isopropyl)phenoxycarbonyloxy]-benzoyl]amino}-propanoic acid;
3-carbamoyl-1-((((2,6-diisopropyl-phenoxy)carbonyl)oxy)methyl)pyridin-1-ium iodide;
3-carbamoyl-1-(((2,6-diisopropylphenoxy)carbonyloxy)methyl)pyridinium mesylate;
3-carboxy-1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)pyridin-1-ium iodide;
3-carboxy-1-((((2,6-diisopropylphenoxy) carbonyl)oxy)methyl)pyridin-1-ium methanesulfonate;
4-[(2S)-2-amino-(3R)-3-hydroxybutyryl]amino-3,3-dimethylbutanoate;
4-[(2S)-2-amino-3-carbamoylpropionylamino]-3,3-dimethylbutanoate;
4-[(2S)-2-amino-4-carboxybutyrylamino]-3,3-dimethylbutanoate;
4-[(2S)-2-aminopropionylamino]-3,3-dimethylbutanoate;
2,6-(Diisopropyl)phenyl;
4-[aminomethylcarbonylamino]-3,3-dimethylbutanoate;
2,6-(Diisopropyl)phenyl;
arginine2-(2,6-diisopropylphenoxy)-2-hydroxyethylphosphate;
arginine2-(2,6-diisopropylphenoxy)-3,4,5-trihydroxytetrahydropyran-6-yl dihydrogen phosphate;
Boc-Asp(OPropofol)-OBzl; Boc-Asp(OPropofol)-OH;
Boc-Glu(OPropofol)-OBzl;
Boe-Glu(OPropofol)-OH;
di[propofol 5-carboxyl-2(S)-fluorohexanoate] zinc salt;
di[propofol 5-carboxyl-2-(S)-fluorohexanoate] zinc salt;
di[propofol 7-carboxyl-2(R,S)-fluorocaprylate] calcium salt;
di[propofol 7-carboxyl-2-(R,S)fluorocaprylate] calcium salt;
disodium lauryl-imino-dipropionate2-(2,6-diisopropylphenoxy) tetrahydropyran-6-yl dihydrogen phosphate;
disodium lauryl-iminodipropionate-2-(2,6-diisopropyl phenoxy) tetrahydropyran-6-yl dihydrogen phosphate;
H-Abu-Asp(OPropofol)-OH;
H-Abu-Thr(γ-OC(O)OPropofol)-OH Hydrochloride;
H-Aib-OCH2OPropofol;
H-Ala-Asn-OPropofol;
H-Ala-Asp(OCH2OPropofol)-OH;
H-AlaAsp(OPropofol)-OH;
H-Ala-Cys(β-SC(O)OPropofol)-OH;
H-Ala-Glu(OPropofol)-OH;
H-Ala-OPropofol Hydrochloride;
H-Ala-Phe-OPropofol;
H-Ala-Ser(β-OC(O)OPropofol)-OH;
H-Ala-Thr(β-OC(O)OPropofol)-OH;
H-Ala-Thr(γ-OC(O)OPropofol)-OH Hydrochloride;
H-Ala-Tyr-OPropofol;
H-Arg-Asp(OPropofol)-OH;
H-Arg-Phe-OPropofol;
H-Arg Thr(γ-OC(O)OPropofol)-OH Tris-Hydrochloride;
H-Asn-Asp(OCH2OPropofol)-OH;
H-Asn-Asp(OPropofol)-OH;
H-Asn-D-Thr(γ-OC(O)OPropofol)-OH;
H-Asn-Glu(OPropofol)-OH;
H-Asn-OPropofol Hydrochloride;
H-Asn-Thr(β-OC(O)OPropofol)-OH;
H-Asn-Thr(γ-OC(O)OPropofol)-OH Hydrochloride;
H-Asn-Tyr-OPropofol;
H-Asp(OCH2OPropofol)-ArgOH;
H-Asp(OCH2OPropofol)-Asp-OH;
H-Asp(OCH2OPropofol)-Lys-OH;
H-Asp(OCH2OPropofol)-OH;
H-Asp(OCH2OPropofol)-Ser-OH;
H-Asp(OPropofol)-Ala-OH;
H-Asp(OPropofol)-Asp-OH;
H-Asp(OPropofol)-Gln-OH;
H-Asp(OPropofol)-Glu-OH;
H-Asp(OPropofol)-Gly-OH;
H-Asp(OPropofol)-Ile-OH;
H-Asp(OPropofol)-Leu-OH;
H-Asp(OPropofol)-Met-OH;
H-Asp(OPropofol)-OBzl;
H-Asp(OPropofol)-OH;
H-Asp(OPropofol)-O-Trityl;
H-Asp(OPropofol)-Phe-OH;
H-Asp(OPropofol)-Pro-OH;
HAsp(OPropofol)-Ser-OH;
H-Asp(OPropofol)-Val-OH;
H-Asp-Ala-OPropofol;
H-Asp-AsnOPropofol;
H-Asp-Asp(OCH2OPropofol)-OH;
H-Asp-Asp(OPropofol)-OH;
H-AspOCH2OPropofol;
H-Asp-Phe-OPropofol;
H-Asp-Ser(β-OC(O)OPropofol)-OH;
H-Asp-TyrOPropofol;
H-Cys-Asp(OPropofol)-OH;
H-Dap(β-NHC(O)OPropofol)-Ala-OH;
H-Dap-Ala-OPropofol;
H-Dap-Asn-OPropofol;
H-Dap-Thr(γ-OC(O)OPropofol)-OH Bis-Hydrochloride;
H-Dap-Tyr-OPropofol;
H-D-Asn-Thr(γ-OC(O)OPropofol)-OH;
H-D-LysThr(γ-OC(O)OPropofol)-OH Bis-Hydrochloride;
H-D-Ser-Thr(γ-OC(O)OPropofol-OH Hydrochloride;
H-Gln-Asn-OPropofol;
H-Gln-Asp(OCH2OPropofol)-OH;
H-Gln-OPropofol Hydrochloride;
H-Gln-Phe-OPropofol;
H-Glu(OPropofol)-Ala-OH;
H-Glu(OPropofol)-ArgOH;
H-Glu(OPropofol)-Asp-OH;
H-Glu(OPropofol)-Gln-OH;
H-Glu(OPropofol)-Glu-OH;
H-Glu(OPropofol)-Gly-OH;
H-Glu(OPropofol)-Ile-OH;
H-Glu(OPropofol)-Leu-OH;
H-Glu(OPropofol)-Lys-OH;
H-Glu(OPropofol)-Met-OH;
H-Glu(OPropofol)-OBzl;
H-Glu(OPropofol)-OH;
H-Glu(OPropofol)-Phe-OH;
H-Glu(OPropofol)-Ser-OH;
H-Glu(OPropofol)-Val-OH;
H-Glu-Asp(OCH2OPropofol)-OH;
H-Glu-Phe-OPropofol;
H-GluTyr-OPropofol;
H-Gly-Asn-OPropofol;
H-Gly-Asp(OCH2OPropofol)-OH;
H-Gly-OPropofol Hydrochloride;
H-Gly-Phe-OPropofol;
H-Gly-Thr(γ-OC(O)OPropofol)-OH;
H-Gly-TyrOPropofol;
H-His-Asp(OCH2OPropofol)-OH;
H-His-OPropofol;
H-His-Phe-OPropofol;
H-His-Thr(γ-OC(O)OPropofol)-OH Bis-Hydrochloride;
H-Leu-Asp(OPropofol)-OH;
H-Leu-D-Thr(γ-OC(O)OPropofol)-OH;
H-Leu-Glu(OPropofol)-OH;
H-Leu-Thr(γ-OC(O)OPropofol)OH Hydrochloride;
H-Lys-Asp(OPropofol)-OH;
H-Lys-Cys(β-SC(O)OPropofol)-OH;
H-Lys-Glu(OPropofol)-OH;
H-Lys-OPropofol Hydrochloride;
H-Lys-Ser(β-OC(O)OPropofol)-OH;
H-Lys-Thr(β-OC(O)OPropofol)-OH;
H-Lys-Thr(γ OC(O)OPropofol)-OH Bis-Hydrochloride;
H-Lys-Tyr-OPropofol;
H-Met-Asp(OPropofol)OH;
H-Met-OPropofol;
H-Met-Thr(γ-OC(O)OPropofol)-OH Hydrochloride;
H-NVal-Asp(OPropofol)-OH;
H-Orn-Asp(OPropofol)-OH;
H-Orn-Thr(γ-OC(O)OPropofol)-OH BisHydrochloride;
H-Phe-Asp(OPropofol)-OH;
H-Phe-OPropofol;
H-Pro-OPropofol Hydrochloride;
H-Pro-Phe-OPropofol;
H-Pro-Thr(γ-OC(O)OPropofol)-OH Hydrochloride;
H-Pro-Tyr-OPropofol;
H-Sar-Asp(OPropofol)-OH;
H-Ser-Asn-OPropofol;
H-SerAsp(OCH2OPropofol)-OH;
H-Ser-Cys(β-SC(O)OPropofol)-OH;
H-Ser-D-Thr(γOC(O)OPropofol)-OH;
H-Ser-OPropofol;
H-Ser-Phe-OPropofol;
H-Ser-Ser(β-OC(O)OPropofol)-OH;
H-Ser-Thr(β-OC(O)OPropofol)-OH;
H-Ser-Thr(γ-OC(O)OPropofol)-OH Hydrochloride
H-Ser-Tyr-OPropofol;
H-ThrAsp(OCH2OPropofol)-OH;
H-Thr-OPropofol Hydrochloride;
H-Thr-Phe-OPropofol;
H-Trp-Asp(OCH2OPropofol)-OH;
H-Trp-Phe-OPropofol;
H-Tyr-Asn-OPropofol;
H-TyrAsp(OCH2OPropofol)-OH;
H-Tyr-Asp(OPropofol)-OH;
H-Tyr-OPropofol Hydrochloride;
H-Tyr-Phe-OPropofol;
H-Tyr-Ser(β-OC(O)OPropofol)-OH;
H-Val-Ala-OPropofol;
H-Val-Asn-OPropofol;
H-Val-OCH2OPropofol;
H-Val-OPropofol;
H-Val-Phe-OPropofol;
H-Val-Ser-OPropofol;
H-Val-Thr(β-OC(O)OPropofol)-OH;
H-Val-Thr(γ-OC(O)OPropofol)-OH Hydrochloride H-Val-Tyr-OPropofol;
2,6-(Diisopropyl)phenyl hydroxybutyrate disodiumphosphate;
2,6-(Diisopropyl)phenyl hydroxyvaleratephosphate disodium salt;
H-[3-Ala-Asp(OPropofol)-OH;
H-[3-Ala-Thr(γ-OC(O)OPropofol)-OH Hydrochloride;
1-Amino-2-[2,6-(diisopropyl)phenoxycarbonyloxy]ethane;
N-(2-Dibutylaminoethyl)-succinamic acid 2,6-diisopropyl-phenyl ester;
N-(2-Dibutylaminoethyl)-succinamic acid 2,6-diisopropyl-phenyl ester hydrochloride;
N-(2-Diethylamino-ethyl)-succinamic acid 2,6-diisopropyl-phenyl ester Hydrochloride;
N-(2-Diethylammoethyl)-succinamic acid 2,6-diisopropylphenyl ester;
N-(2-Diisopropylaminoethyl)-succinamic acid 2,6-diisopropyl-phenyl ester;
N-(2-Diisopropylamino-ethyl)-succinamic acid 2,6-diisopropyl phenyl ester Hydrochloride;
N-(2-Dimethylamino-ethyl)-succinamic acid 2,6-diisopropyl-phenyl ester Hydrochloride;
N-(2-Dimethylaminoethyl)-succinamic acid 2,6-diisopropyl-phenyl ester;
N-(2-Morpholin-4-ylethyl)-succinamic acid 2,6-diisopropylphenyl ester;
N-(2-Morpholin-4-yl-ethyl)-succinamic acid 2,6-diisopropylphenyl ester Hydrochloride;
N-(2-Piperidin-1-yl-ethyl)-succinamic acid 2,6-diisopropylphenyl ester;
N-(2-Piperidin-1-yl-ethyl)-succinamic acid 2,6-diisopropylphenyl ester hydrochloride;
N-(2-Pyrrolidin-1-yl-ethyl)-succinamic acid 2,6-diisopropylphenyl ester;
N-(2-Pyrrolidin-1-yl-ethyl)-succinamic acid 2,6-diisopropylphenyl ester hydrochloride;
O-[t-butoxycarbonyl]-propofol);
propofol 2-carboxyl-2(S)fluoropropionate sodium salt;
propofol 3-(N,N-diethyl)amino-2-(R,S)-fluoropropionate hydrochloride;
propofol 3-(N-isopropyl)amino-2-(R,S)-2-monofluoromethylpropionate methanesulfonate;
propofol 3-(N-isopropyl)amino-2(R,S)-2-monofluoromethyl propionate methanesulfonate;
propofol 3-(pyrrolidin-1-yl)-2-(S)-trifluoromethyl propionate hydrochloride;
propofol 3-(pyrrolidin-1-yl)-2(S)-trifluoromethylpropionate hydrochloride;
propofol 3-carboxyl-2(R)-fluorobutyrate sodium salt; propofol 3-N-isopropylamino-2-(R,S)-fluoropropionate hydrochloride;
propofol 3-N-methyl-N-cyclohexylamino-2-(R,S)fluoropropionate hydrochloride;
propofol 3-N-methyl-N-cyclohexylamino-2-(R,S)fluoropropionate hydrochloride;
propofol 3-phosphoryl-2-(R,S)-fluoropropionate zinc salt;
propofol 4-(aziridin-1-yl)-2-(S)-2-fluorobutyratehydrochloride;
propofol 4-(N,Ndimethyl)amino-2-(R)-2-trifluoromethylbutyrate hydrochloride;
propofol 4-(N,Ndimethyl)amino-2-(R)-fluorobutyrate hydrochloride;
propofol 4-(N,N-dimethyl)amino-2-(R)trifluoromethylbutyrate hydrochloride;
propofol 4-(N,N-dimethyl)amino-2-(R,S)fluorobutyrate hydrochloride;
propofol 4-(N-cyclopropyl-N-methyl)amino-2-(R)difluoromethylbutyratehydrochloride;
propofol 4-(N-methyl-N-benzyl)amino-2-(R,S)trifluoromethylbutyrate hydrochloride;
propofol 4-(N-methyl-N-ethyl)amino-2-(R,S)-2-fluorobutyratehydrochloride;
propofol 4-(N-methyl-N-isopropyl)amino-2-(R,S)fluorobutyrate methanesulfonate;
propofol 4-(pyrrolidin-1-yl)-2-(R)-2-fluorobutyrate hydrochloride;
propofol 4-carboxyl-2-(R)-2-trifluoromethylvalerate lithium salt;
propofol 4-carboxyl-2(R)-fluorobutyrate sodium salt;
propofol 4-carboxyl-2-(R,S)difluoromethylvalerate potassium salt;
propofol 4-carboxyl-2(R,S)-fluorovalerate sodium salt;
propofol 4-carboxyl-2(S)-fluorovalerate potassium salt;
propofol 4-carboxyl-2-(S)fluorovalerate potassium salt;
propofol 4-carboxyl-2-(S)-trifluoromethylbutyrate ammonium salt;
propofol 4-N-(aziridin-1-yl)-2(S)-2-fluorobutyrate hydrochloride;
propofol 4-N-methyl-N-benzylamino-2-(R)-fluorobutyrate hydrochloride;
propofol 4-phosphoryl-2-(R)fluorobutyrate disodium salt;
propofol 4-phosphoryl-2-(R,S)-fluorobutyrate calcium salt;
propofol 5-(N-methyl-N-benzyl)amino-2-(S)-2-fluorovalerate hydrochloride;
propofol 5-carboxyl-2-(R,S)-difluoromethylvalerate potassium salt;
propofol 5-N-cyclopentylamino-2,2-difluorovalerate hydrochloride;
propofol 5-phosphoryl-2-(S)-fluorovalerate zinc salt;
propofol 6-(N,N-dimethyl)amino-2(R)-fluorovalerate hydrochloride;
Propofol Hemisuccinate;
propofol hydroxybutyrate;
propofol hydroxyvalerate;
propofol 8-(N,Ndimethyl)amino-2-(R)-fluorovaleratehydrochloride;
propofol-2-(R)-fluoropropionate monoester sodium salt;
propofol-2-(R,S)-fluorobutyratemonoester sodium salt;
propofol-2-(R,S)-fluoropentanoate monoester sodium salt;
(S)-2-amino-3-(2,6-diisopropylphenoxycarbonyloxy)-propanoic acid mesylate;
Sodium 4-(2,6-Diisopropyl phenoxy)-4-oxobuty 1 Phosphate;
2-(2,6-diisopropyl phenoxy)-tetrahydropyran-6-yl dihydrogen phosphate arginine;
tri[propofol 3-phosphoryl-2-(R,S)-2-monofluoromethylpropionate] dialuminum salt;
tri[propofol 8-carboxyl-2-(R,S)monofluoromethylpelargonate]aluminum salt; Succinic Acid Mono-Propofol Ester;
BOC-protected 1-deoxy-1-hydrazinoglucitol;
2-amino-3-methyl-3-(2,6-diisopropyl-phenoxycarbonyloxy)-propanoic acid;
2-amino-3-(2,6-diisopropylphenoxycarbonyloxy)-propanoic acid;
1-(2,6-diisopropyl phenoxy)ethyl dihydrogen phosphate;
Mono(propofol) phosphate;
Di(propofol) phosphate;
Carboxylic hemiesters of propofol;
hemisuccinate ester of propofol;
hemiglutarate ester of propofol;
hemiadipate ester of propofol;
(2′,6′-Diisopropylphenyl4-(2-trimethylammoniumethyloxy) phosphonobutyrate);
(2′,6′-Diisopropylphenyl3-ortho-(O-trimethylammonium ethylphosphonooxy)-1-propionate)
(4-(2,6-diisopropylphenoxy)-4-oxobutanoyl)glycine;
4-(4-(2,6-diisopropylphenoxy)-4-oxobutanamido)butanoic acid
HX0507;
HX0969w;
HX0892;
HX0891;
propofol methoxymethylphosphonic prodrug;
propofol hemiglutarate;
propofol hemiadipate;
monopropofol phosphate;
dipropofol phosphate;
1-(((2,6-diisopropylphenoxy)carbonyloxy)methyl)-3-(dimethylcarbamoyl)pyridinium mesylate;
1-(((2,6-diisopropylphenoxy)carbonyloxy)methyl)-3-(methylcarbamoyl)pyridinium mesylate;
3-carbamoyl-1-(((2,6-diisopropylphenoxy)carbonyloxy)methyl)pyridinium mesylate;
1-(((2,6-diisopropyl phenoxy)carbonyloxy)methyl)-3-(methylcarbamoyl)pyridinium iodide;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-3-(dimethylcarbamoyl)pyridin-1-ium methanesulfonate;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-3-(dimethylcarbamoyl)pyridin-1-ium iodide;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-3-(methoxycarbonyl)pyridin-1-ium iodide;
3-carboxy-1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)pyridin-1-ium iodide;
2-(((2,6-diisopropylphenoxy)carbonyl)oxy)-N,N,N-trimethylethan-1-aminium iodide;
2-(((2,6-diisopropylphenoxy)carbonyl)oxy)-N,N-dimethylethan-1-aminium chloride;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-3-(hydroxycarbamoyl)pyridin-1-ium iodide;
3-(((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)carbamoyl)-1-methylpyridin-1-ium iodide;
1-(((2,6-diisopropylphenoxy)carbonyl)oxy)-N-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-N,N-dimethylmethanaminiumiodide;
2-(((2,6-diisopropylphenoxy)carbonyl)oxy)-N-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)N,N-dimethylethan-1-aminiumiodide;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-4-formyl-3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-1-ium iodide;
3-((2,6-diisopropylphenoxy)carbonyl)-1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)pyridin-1-ium methanesulfonate;
2-(((2,6-diisopropylphenoxy)carbonyl)oxy)-N,N,N-trimethylethan-1-aminium methanesulfonate;
3-carbamoyl-1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methy)pyridin-1-ium bromide;
3-carbamoyl-1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)pyridin-1-ium chloride;
1-((((2,6-diisopropyl phenoxy)carbonyl)oxy)methyl)-3-(methylcarbamoyl)pyridin-1-ium tetrafluoroborate;
1-((((2,6-diisopropyl phenoxy)carbonyl)oxy)methyl)-3-(methylcarbamoyl)pyridin-1-ium nitrate;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-3-(methylcarbamoyl)pyridin-1-ium chloride;
1-((((2,6-diisopropylphenoxy)carbonyl)oxy)methyl)-3-(methoxycarbonyl)pyridin-1-ium methanesulfonate; or
3-carboxy-1-((((2,6-diisopropyl phenoxy)carbonyl)oxy)methyl)pyridin-1-ium methanesulfonate.