US 12,377,078 B2
Viral inhibitors, the synthesis thereof, and intermediates thereto
Jeffrey Scott Depue, Windham, NH (US); Suresh Kumar Tipparaju, Arlington, MA (US); Helge Alfred Reisch, Sarasota, FL (US); Datong Tang, Weston, MA (US); and Kishore Ramachandran, Westford, MA (US)
Assigned to Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed by Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed on Jul. 18, 2024, as Appl. No. 18/777,489.
Application 18/777,489 is a continuation of application No. 18/379,047, filed on Oct. 11, 2023.
Claims priority of provisional application 63/415,438, filed on Oct. 12, 2022.
Prior Publication US 2024/0366646 A1, Nov. 7, 2024
Int. Cl. C07H 19/052 (2006.01); A61K 9/00 (2006.01); A61K 31/4184 (2006.01); A61K 31/7056 (2006.01)
CPC A61K 31/4184 (2013.01) [A61K 9/0053 (2013.01); A61K 31/7056 (2013.01); C07H 19/052 (2013.01)] 26 Claims
 
1. A method of preparing compound 2

OG Complex Work Unit Chemistry
or a salt thereof, comprising
reacting compound 5:

OG Complex Work Unit Chemistry
or a salt thereof,
with compounds 6 and 7:

OG Complex Work Unit Chemistry
to provide compound 2,
wherein the reaction takes place in the presence of 1,4-dioxane.