US 12,377,059 B2
Complexes comprising collagen peptides and curcuminoids and compositions thereof
Krishnakumar Illathu Madhavamenon, Kerala (IN); and Balu Paulose Maliakel, Kerala (IN)
Assigned to AKAY NATURAL INGREDIENTS PRIVATE LIMITED, Cochin (IN)
Filed by AKAY NATURAL INGREDIENTS PRIVATED LIMITED, Cochin (IN)
Filed on Jul. 17, 2023, as Appl. No. 18/353,251.
Application 18/353,251 is a continuation of application No. 16/773,494, filed on Jan. 27, 2020, abandoned.
Claims priority of application No. 201941003319 (IN), filed on Jan. 28, 2019.
Prior Publication US 2024/0050381 A1, Feb. 15, 2024
Int. Cl. A61K 31/12 (2006.01); A61K 9/08 (2006.01); A61K 9/107 (2006.01); A61K 9/19 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 36/73 (2006.01); A61K 36/9066 (2006.01); A61K 38/01 (2006.01); A61K 38/39 (2006.01); A61K 47/10 (2017.01); A61K 47/14 (2017.01); A61K 47/26 (2006.01); A61K 47/36 (2006.01)
CPC A61K 31/12 (2013.01) [A61K 9/08 (2013.01); A61K 9/1075 (2013.01); A61K 9/19 (2013.01); A61K 9/20 (2013.01); A61K 9/48 (2013.01); A61K 36/73 (2013.01); A61K 36/9066 (2013.01); A61K 38/014 (2013.01); A61K 38/39 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/26 (2013.01); A61K 47/36 (2013.01)] 12 Claims
 
1. A method of preparing water soluble pharmaceutical composition, comprising the steps of:
a. micronising hydrophobic bioactive molecules to form micronized hydrophobic bioactive molecules;
b. emulsifying the micronized hydrophobic bioactive molecules by homogenisation with an emulsifier with phosphatidylcholines to form emulsified hydrophobic bioactive molecules;
c. dissolving collagen peptides in water at a concentration range of 20 to 95% to form dissolved collagen peptides;
d. sonicating the emulsified hydrophobic bioactive molecules from step (b) with the dissolved collagen peptides from step (c) to form a complex of hydrophobic bioactive molecules;
e. encapsulating the complex from step (d) by ultrasound mediated homogenisation to form encapsulated complex of hydrophobic bioactive molecules; and
f. drying the encapsulated complex from step (e) by spray drying or freeze drying to form the water soluble pharmaceutical composition;
wherein said collagen peptides form an amorphous, nano-sized non-covalent complex with the hydrophobic bioactive molecules and encapsulated in the collagen peptide matrix, and wherein the hydrophobic bioactive molecules are selected from the group consisting of curcuminoids, gingerol, flavonoids, stilbenes, carotenoids, terpenes, terpenoids, and chlorophyll.