US 12,377,055 B2
Dissolvable gel-forming film for delivery of active agents
Lei Shi, Mansfield, TX (US); Aleksa Jovanovic, Fort Worth, TX (US); and Dennis Carson, Burleson, TX (US)
Assigned to SMITH & NEPHEW, INC., Memphis, TN (US)
Filed by SMITH & NEPHEW, INC., Memphis, TN (US)
Filed on May 17, 2024, as Appl. No. 18/667,290.
Application 18/667,290 is a continuation of application No. 17/892,435, filed on Aug. 22, 2022, granted, now 12,023,412.
Application 17/892,435 is a continuation of application No. 14/769,754, granted, now 11,452,698, previously published as PCT/US2014/024410, filed on Mar. 12, 2014.
Claims priority of provisional application 61/790,132, filed on Mar. 15, 2013.
Prior Publication US 2024/0382433 A1, Nov. 21, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/70 (2006.01); A61K 38/48 (2006.01); A61K 47/10 (2017.01); A61K 47/38 (2006.01); A61L 15/28 (2006.01); A61L 15/38 (2006.01); A61L 15/44 (2006.01); A61L 15/60 (2006.01); A61L 15/62 (2006.01)
CPC A61K 9/7007 (2013.01) [A61K 38/4873 (2013.01); A61K 38/4886 (2013.01); A61K 47/10 (2013.01); A61K 47/38 (2013.01); A61L 15/28 (2013.01); A61L 15/38 (2013.01); A61L 15/44 (2013.01); A61L 15/60 (2013.01); A61L 15/62 (2013.01); C12Y 304/22002 (2013.01); C12Y 304/24027 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of applying a dissolvable, gel-forming film to a surface,
wherein the dissolvable, gel-forming film comprises a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and a protease,
wherein the dissolvable, gel-forming film has a water content of less than 15% w/w, and
wherein the dissolvable, gel-forming film is capable of forming a hydrogel when 1 gm of gel-forming film is contacted with 20 ml of water or other aqueous medium.