US 12,377,045 B2
Oral liquid formulations of lipid-lowering and blood pressure-lowering drugs
Sydney Ugwu, North Brunswick, NJ (US); Zengli Fu, Kendall Park, NJ (US); and James He, Green Brook, NJ (US)
Assigned to FORDOZ PHARMA CORP., East Windsor, NJ (US)
Appl. No. 17/768,049
Filed by FORDOZ PHARMA CORP., East Windsor, NJ (US)
PCT Filed Nov. 24, 2020, PCT No. PCT/US2020/061911
§ 371(c)(1), (2) Date Apr. 11, 2022,
PCT Pub. No. WO2021/108343, PCT Pub. Date Jun. 3, 2021.
Claims priority of provisional application 62/939,729, filed on Nov. 25, 2019.
Prior Publication US 2024/0091147 A1, Mar. 21, 2024
Int. Cl. A61K 9/08 (2006.01); A61K 31/216 (2006.01); A61K 31/366 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/4422 (2006.01); A61K 47/12 (2006.01); A61K 47/14 (2017.01); A61K 47/26 (2006.01); A61K 47/44 (2017.01)
CPC A61K 9/08 (2013.01) [A61K 31/216 (2013.01); A61K 31/366 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/4422 (2013.01); A61K 47/12 (2013.01); A61K 47/14 (2013.01); A61K 47/26 (2013.01); A61K 47/44 (2013.01)] 22 Claims
 
1. An oral liquid formulation, comprising: (a) a combination of drugs wherein the drugs are selected from the group consisting of ezetimibe, statins, fenofibrate, amlodipine, valsartan, candesartan, telmisartan, losartan and salts thereof; (b) about 20% to about 90% w/w of one or more non-ionic surfactants that are liquids at ambient conditions; (c) about 0.05% to about 7.5% w/w of a co-solvent selected from the group consisting of an oil, glycerin, propylene glycol, polyethylene glycols that are liquids at ambient conditions, C1-C6 straight and branch monoalcohols and combinations thereof; (d) about 0.1% to about 5% w/w of a buffering agent, and (e) water wherein if present the ezetimibe is present in an amount of 0.05% to 10% w/w and if present the statins, fenofibrate, amlodipine, valsartan, candesartan, telmisartan, losartan and salts thereof are present in an amount of 0.05% to 20% w/w.