US 12,377,044 B2
Method and device for transdermal delivery of parathyroid hormone using a microprojection array
Parminder Singh, Union City, CA (US); Danir Bayramov, Irvine, CA (US); Guohua Chen, Sunnyvale, CA (US); and Robert Wade Worsham, Sutter Creek, CA (US)
Assigned to Panther Life Sciences Corporation, Normandy Park, WA (US)
Filed by Panther Life Sciences Corporation, Normandy Park, WA (US)
Filed on Jul. 15, 2022, as Appl. No. 17/812,995.
Application 16/786,906 is a division of application No. 15/623,305, filed on Jun. 14, 2017, abandoned.
Application 17/812,995 is a continuation of application No. 16/786,906, filed on Feb. 10, 2020, granted, now 11,419,816.
Application 15/623,305 is a continuation of application No. 13/101,071, filed on May 4, 2011, granted, now 9,687,641, issued on Jun. 27, 2017.
Claims priority of provisional application 61/331,226, filed on May 4, 2010.
Prior Publication US 2023/0027289 A1, Jan. 26, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 38/29 (2006.01); A61K 47/22 (2006.01); A61K 47/26 (2006.01); A61K 47/34 (2017.01); A61K 47/36 (2006.01); A61M 37/00 (2006.01)
CPC A61K 9/0021 (2013.01) [A61K 38/29 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61K 47/34 (2013.01); A61K 47/36 (2013.01); A61M 37/0015 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0061 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A microprotrusion array for transdermal administration of a dose of parathyroid hormone (PTH) to a mammalian subject, said array comprising a plurality of microprotrusions extending from an approximately planar base, each microprotrusion of the plurality of microprotrusions comprising an end portion distal to the planar base and an upper portion proximal to the planar base,
wherein at least the end portion of each microprotrusion of the plurality of microprotrusions comprises a portion of the dose of the PTH in a water-soluble polymer matrix, the water-soluble polymer matrix comprising:
(i) about 7.5-12.8% dry weight PTH;
(ii) about 20-70% dry weight of at least one dextran polymer; and
(iii) about 10-35% dry weight of at least one sugar or sugar alcohol; and
wherein the upper portion of each microprotrusion of the plurality of microprotrusions comprises at least one water-insoluble polymer.