	US 12,377,037 B2
	Cleavable comonomer strategy for accelerating removal of gel nail polish
Jeremiah A. Johnson, Boston, MA (US); Leticia C. Cardoso Da Costa, Somerville, MA (US); Elisabeth Prince, Waterloo (CA); and Alexandra Johnson, Boston, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Appl. No. 18/718,795
Filed by MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US)
PCT Filed Dec. 1, 2023, PCT No. PCT/US2023/082177 § 371(c)(1), (2) Date Jun. 11, 2024, PCT Pub. No. WO2024/119140, PCT Pub. Date Jun. 6, 2024.
Claims priority of provisional application 63/482,995, filed on Feb. 2, 2023.
Claims priority of provisional application 63/429,438, filed on Dec. 1, 2022.
Prior Publication US 2024/0423894 A1, Dec. 26, 2024
Int. Cl. A61K 8/81 (2006.01); A61Q 3/02 (2006.01)

CPC A61K 8/8105 (2013.01) [A61Q 3/02 (2013.01); A61K 2800/81 (2013.01)]

18 Claims

1. A polymer composition, comprising:

a first monomer of Formula I or a tautomer or salt thereof

wherein R¹, R², and R³are independently selected from a group consisting of: hydrogen, halogen, or substituted or unsubstituted alkyl; and

R⁴is selected from a group consisting of: halogen, substituted or unsubstituted alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —CN, —OR^a—SCN, —SR^a—SSR^a—N₃, —NO, —N(R^a)₂, —NO₂, —C(═O)R^a, —C(═O)OR^a, —C(═O)SR^a, —C(═O)N(R^a)₂, —C(═NR^a)R^a, —C(═NR^a)OR^a, —C(═NR^a)SR^a, —C(═NR^a)N(R^a)₂, —S(═O)R^a, —S(═O)OR^a, —S(═O)SR^a, —S(═O)N(R^a)₂, —S(═O)₂R^a, —S(═O)₂OR^a, —S(═O)₂SR^a, —S(═O)₂N(R^a)₂, —OC(═O)R^a, OC(═O)OR^a, —OC(═O)SR^a, —OC(═O)N(R^a)₂, —OC(═NR^a)R^a, —OC(═NR^a)OR^a, OC(═NR^a)SR^a, OC(═NR^a)N(R^a)₂, —OS(═O)R^a—OS(═O)OR^a, —OS(═O)SR^a, —OS(═O)N(R^a)₂, —OS(═O)₂R^a, —OS(═O)₂OR^a, —OS(═O)₂SR^a, —OS(═O)₂N(R^a)₂, —ON(R^a)₂, —SC(═O)R^a, —SC(═O)OR^a, —SC(═O)SR^a, —SC(═O)N(R^a)₂, —SC(═NR^a)R^a, —SC(═NR^a)OR^a, —SC(═NR^a)SR^a, —SC(═NR^a)N(R^a)₂, —NR^aC(═O) R^a—NR^aC(═O)OR^a, —NR^aC(═O)SR^a, —NR^aC(═O)N(R^a)₂, —NR^aC(═NR^a)R^a, —NR^aC(═NR^a)OR^a, —NR^aC(═NR^a)SR^a, —NR^cC(═NR^a)N(R^a)₂, —NR^aS(═O)R^a, —NR^aS(═O)OR^a, —NR^aS(═O)SR^a, —NR^aS(═O)N(R^a)₂, —NR^aS(═O)₂R^a, —NR^aS(═O)₂OR^a, —NR^aS(═O)₂SR^a, —NR^aS(═O)₂N(R^a)₂, —Si(R^a)₃, —Si(R^a)₂OR^a, —Si(R^a)(OR^a)₂, —Si(OR^a)₃, OSi(R^a)₃, —OSi(R^a)₂OR^a, —OSi(R^a)(OR^a)₂, or —OSi(OR^a)₃;

wherein each instance of R^ais independently selected from a group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom;

a second monomer comprising two or more non-aromatic unsaturated carbon-carbon bonds; and

a third monomer of Formula IV or a tautomer or salt thereof