US 12,376,814 B2
Quantification of noncalcific and calcific valve tissue from coronary CT angiography
Damini Dey, Los Angeles, CA (US); Sebastien Cadet, Los Angeles, CA (US); Piotr Slomka, Los Angeles, CA (US); and Rajendra Makkar, Beverly Hills, CA (US)
Assigned to CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA (US)
Filed by CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA (US)
Filed on Nov. 23, 2022, as Appl. No. 17/993,819.
Claims priority of provisional application 63/287,868, filed on Dec. 9, 2021.
Claims priority of provisional application 63/282,853, filed on Nov. 24, 2021.
Prior Publication US 2023/0157658 A1, May 25, 2023
Int. Cl. A61B 6/50 (2024.01); A61B 6/00 (2006.01)
CPC A61B 6/504 (2013.01) [A61B 6/5217 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A system, comprising:
one or more data processors; and
a non-transitory computer-readable storage medium containing instructions which, when executed on the one or more data processors, cause the one or more data processors to perform operations including:
receiving imaging data of a portion of a heart containing a valve;
determining a region of interest, wherein the region of interest contains the valve;
generating cross-sectional images of the region of interest based at least in part on the determined region of interest and the received imaging data;
identifying both calcific tissue components and noncalcific tissue components within the region of interest based at least in part on the generated cross-sectional images;
calculating a calcific tissue volume based at least in part on the calcific tissue components;
calculating a noncalcific tissue volume based at least in part on the noncalcific tissue components; and
calculating a fibrocalcific volume associated with the valve based at least in part on the calcific tissue volume and the noncalcific tissue volume.