US 12,366,569 B2
Method for detecting SLE
Akiyoshi Hirayama, Tsuruoka (JP); Tomoyoshi Soga, Tsuruoka (JP); Shoichi Maruyama, Nagoya (JP); and Shinichi Akiyama, Nagoya (JP)
Assigned to Keio University, Tokyo (JP); and National University Corporation National Higher Education and Research System, Nagoya (JP)
Appl. No. 17/417,640
Filed by Keio University, Tokyo (JP); and National University Corporation Tokai National Higher Education and Research System, Nagoya (JP)
PCT Filed Dec. 26, 2019, PCT No. PCT/JP2019/051066
§ 371(c)(1), (2) Date Jun. 23, 2021,
PCT Pub. No. WO2020/138260, PCT Pub. Date Jul. 2, 2020.
Claims priority of application No. 2018-242371 (JP), filed on Dec. 26, 2018.
Prior Publication US 2022/0120730 A1, Apr. 21, 2022
Int. Cl. G01N 33/493 (2006.01)
CPC G01N 33/493 (2013.01) [G01N 2560/00 (2013.01); G01N 2800/104 (2013.01); G01N 2800/52 (2013.01)] 9 Claims
 
1. A method for treating systemic lupus erythematosus, comprising:
(a) a step of measuring the concentration of 3′,4′-didehydro-3′-deoxycytidine in urine collected from a test subject;
(b) a step of comparing the concentration of 3′,4′-didehydro-3′-deoxycytidine measured in step (a) with a reference concentration for control;
(c) a step of diagnosing the test subject as having systemic lupus erythematosus wherein
the concentration of 3′,4′-didehydro-3′-deoxycytidine measured in the step (a) is higher than the reference concentration for control; and
(d) a step of administering an immunosuppressive treatment to the test subject diagnosed with system lupus ervthematosus.