US 12,365,655 B2
Compounds
H. Rachel Lagiakos, Parkville (AU); Richard Charles Foitzik, Parkville (AU); Catherine Fae Hemley, Melbourne (AU); Michelle Ang Camerino, Parkville (AU); Paul Anthony Stupple, Parkville (AU); Ylva Elisabet Bergman Bozikis, Parkville (AU); and Scott Raymond Walker, Parkville (AU)
Assigned to CTXT PTY LTD, Melbourne (AU)
Filed by CTXT PTY LTD, Melbourne (AU)
Filed on Aug. 3, 2021, as Appl. No. 17/392,356.
Application 17/392,356 is a continuation of application No. 16/446,868, filed on Jun. 20, 2019, abandoned.
Claims priority of application No. 1810092 (GB), filed on Jun. 20, 2018.
Prior Publication US 2022/0153710 A1, May 19, 2022
Int. Cl. C07D 261/20 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01)
CPC C07D 261/20 (2013.01) [C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01)] 14 Claims
 
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof:

OG Complex Work Unit Chemistry
wherein:
R1, R2, R3 and R4 are independently selected from the group consisting of:
(i) H;
(ii) C1-3 alkyl, optionally substituted by:
hydroxy,
C1-2 alkoxy,
NH2,
phenyl,
C5-6 heteroaryl,
C1-4 alkyl carbamoyl, or
acylamido;
(iii) C1-3 alkoxy, optionally substituted by C3-6 cycloalkyl or by one or more fluoro groups;
(iv) C3-6 cycloalkyl;
(v) halo;
(vi) CORC, where RC is selected from NRN1RN2, where RN1 and RN2 are independently selected from H and methyl;
(vii) cyano, NH2, or NO2; and
(viii) phenyl or C5-6 heteroaryl, optionally substituted by methyl, hydroxy or methoxy; and
Ar is a phenyl, optionally substituted by one or more groups selected from the group consisting of:
(i) C1-4 alkyl, optionally substituted by hydroxy, C1-2 alkoxy, NH2, C1-4 alkyl carbamoyl, or by one or more fluoro groups;
(ii) C3-6 cycloalkyl;
(iii) hydroxy; cyano; NRN3RN4, where RN3 and RN4 are independently selected from H and methyl; or acylamido;
(iv) halo;
(v) C1-3 alkoxy, optionally substituted by hydroxy, C(O)NH2, C3-6 cycloalkyl, phenyl, C5-6 heteroaryl, or by one or more fluoro groups;
(vi) phenoxy, optionally substituted by fluoro;
(vii) phenyl or C5-6 heteroaryl; and
(viii) SF5 or SO2CH3;
and wherein at least one of R1, R2, R3 and R4 is not H.