US 12,364,978 B2
Anionic exchange-hydrophobic mixed mode chromatography resins
Christopher Belisle, Walnut Creek, CA (US); Xuemei He, Walnut Creek, CA (US); Hong Chen, San Ramon, CA (US); Yueping Xu, Albany, CA (US); and Jiali Liao, San Ramon, CA (US)
Assigned to BIO-RAD LABORATORIES, INC., Hercules, CA (US)
Filed by BIO-RAD LABORATORIES, INC., Hercules, CA (US)
Filed on Feb. 9, 2024, as Appl. No. 18/437,294.
Application 18/437,294 is a division of application No. 17/012,108, filed on Sep. 4, 2020, granted, now 11,896,969.
Claims priority of provisional application 62/896,196, filed on Sep. 5, 2019.
Prior Publication US 2024/0261775 A1, Aug. 8, 2024
Int. Cl. B01J 41/14 (2006.01); B01J 41/07 (2017.01); B01J 47/014 (2017.01); B01J 47/02 (2017.01); C07K 1/18 (2006.01); C12N 9/88 (2006.01)
CPC B01J 41/14 (2013.01) [B01J 41/07 (2017.01); B01J 47/014 (2017.01); B01J 47/02 (2013.01); C07K 1/18 (2013.01); C12N 9/88 (2013.01); C12Y 402/01045 (2013.01); B01J 2220/52 (2013.01)] 6 Claims
 
1. A chromatography resin having the following formula:

OG Complex Work Unit Chemistry
or an anionic salt thereof,
wherein:
X is a spacer;
R2 is C2 to C6 alkyl or C4 to C6 cycloalkyl;
L is NR4, O, or S;
n=1 or 2; and
Ar is a 6-10 membered ring and:
if Ar is aryl, the aryl is optionally substituted with up to five C1 to C3 unsubstituted alkyl, C3 to C6 branched alkyl, unsubstituted aryl, or fluorine groups; or
if Ar is heteroaryl, the heteroaryl is optionally substituted with up to four unsubstituted alkyl groups.