US 12,364,863 B2
Adaptive chronic pain relief via implanted electrical neurostimulation
Qinghuang Lin, Yorktown Heights, NY (US); Jeffrey Rogers, Briarcliff Manor, NY (US); Giovanni Russo, Smithfield Market (IE); Andrea Simonetto, Leixlip (IE); and Tigran Tchrakian, Castleknock (IE)
Assigned to Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed by Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed on Aug. 10, 2023, as Appl. No. 18/232,708.
Application 18/232,708 is a continuation of application No. 17/847,671, filed on Jun. 23, 2022, granted, now 11,826,570.
Application 17/847,671 is a continuation of application No. 16/417,516, filed on May 20, 2019, granted, now 11,389,655.
Claims priority of provisional application 62/674,991, filed on May 22, 2018.
Prior Publication US 2023/0381517 A1, Nov. 30, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/00 (2006.01); A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/11 (2006.01); A61B 5/16 (2006.01); A61N 1/05 (2006.01); A61N 1/36 (2006.01); A61N 1/372 (2006.01); A61B 5/021 (2006.01); A61B 5/08 (2006.01)
CPC A61N 1/36071 (2013.01) [A61B 5/0205 (2013.01); A61B 5/112 (2013.01); A61B 5/165 (2013.01); A61B 5/4824 (2013.01); A61N 1/0551 (2013.01); A61N 1/36132 (2013.01); A61N 1/36139 (2013.01); A61N 1/37217 (2013.01); A61N 1/37247 (2013.01); A61N 1/37264 (2013.01); A61B 5/021 (2013.01); A61B 5/0816 (2013.01); A61N 1/0534 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A computing system for evaluating programming changes of an implantable electrical neurostimulation device for treating chronic pain of a human subject, the computing system comprising:
a storage medium to store patient state data, the patient state data including at least one measurement of a patient state that corresponds to pain experienced by the human subject;
processing circuitry to operate a dynamical model to process the patient state data, the dynamical model implemented in a system that is trained to evaluate outcomes from explored changes over time to a plurality of neurostimulation programming parameters previously used for pain treatment in the human subject,
wherein the dynamical model uses at least one dynamic equation that evaluates the explored changes to the plurality of neurostimulation programming parameters in the human subject using predicted states at multiple times in a modeled future time period, based on the explored changes being compliant within constraints of available programs operable with the neurostimulation device,
wherein the dynamical model evaluates modeled parameter combinations that are customized to the human subject to determine that the explored changes to the plurality of neurostimulation programming parameters with the predicted states provide an improvement to the patient state relative to the plurality of neurostimulation programming parameters previously used, when applied by the neurostimulation device, and
wherein the dynamical model determines the improvement to the patient state in the modeled future time period based on a comparison of: a predicted pain condition of the human subject and a previously observed pain condition of the human subject; and
communication circuitry to transmit commands that cause programming of the implantable electrical neurostimulation device based on the explored changes to the plurality of neurostimulation programming parameters.