US 12,364,662 B2
Phosphatidylcholine lipid liposomes as boundary lubricants in aqueous media
Jacob Klein, Rehovot (IL); Ronit Goldberg, Rehovot (IL); Yechezkel Barenholtz, Jerusalem (IL); and Avi Schroeder, Moshav Massuout Yitzhak (IL)
Assigned to YEDA RESEARCH AND DEVELOPMENT CO., LTD., Rohobot (IL); and YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD., Jerusalem (IL)
Filed by Jacob Klein, Rehovot (IL); Ronit Goldberg, Rehovot (IL); Yechezkel Barenholtz, Jerusalem (IL); and Avi Schroeder, Moshav Massuout Yitzhak (IL)
Filed on Nov. 10, 2022, as Appl. No. 17/984,761.
Application 17/984,761 is a division of application No. 16/809,816, filed on Mar. 5, 2020, granted, now 11,541,008.
Application 16/809,816 is a division of application No. 13/704,866, abandoned, previously published as PCT/IL2011/000477, filed on Jun. 16, 2011.
Claims priority of provisional application 61/355,573, filed on Jun. 17, 2010.
Prior Publication US 2023/0080018 A1, Mar. 16, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/127 (2025.01); A61L 27/50 (2006.01)
CPC A61K 9/127 (2013.01) [A61L 27/50 (2013.01); A61L 2400/10 (2013.01); A61L 2430/24 (2013.01)] 10 Claims
 
1. A method for lubricating one or more biological surfaces that are subjected to pressure of above 3 MPa in a mammalian subject, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the liquid-crystalline to gel-phase transition temperature Tm of said liposomes, wherein the gel-phase liposomes comprise two or more phosphatidylcholine lipids selected from the group consisting of hydrogenated soy phosphatidylcholine (HSPC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and dipalmitoylphosphatidylcholine (DPPC), wherein the molar ratio of the two or more phosphatidylcholine lipids being adjusted to produce liposomes having a Tm value of not less than 45° C. and wherein the biological surface is a cartilage surface within the joint.