US 12,036,292 B2
Heterobiaryl compounds and imaging agents for imaging huntingtin protein
Longbin Liu, Thousand Oaks, CA (US); Celia Dominguez, Los Angeles, CA (US); Xuemei Chen, Voorheesville, NY (US); and John E. Mangette, Town of Lancaster, NY (US)
Assigned to CHDI Foundation, Inc., New York, NY (US)
Filed by CHDI Foundation, Inc., New York, NY (US)
Filed on Aug. 5, 2021, as Appl. No. 17/395,055.
Claims priority of provisional application 63/062,310, filed on Aug. 6, 2020.
Prior Publication US 2022/0040336 A1, Feb. 10, 2022
Int. Cl. A61K 51/04 (2006.01); C07D 239/28 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 471/04 (2006.01)
CPC A61K 51/0459 (2013.01) [C07D 239/28 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 471/04 (2013.01); C07B 2200/05 (2013.01)] 14 Claims
 
1. A compound of Formula III:

OG Complex Work Unit Chemistry
or an isotopically enriched analog, pharmaceutically acceptable salt, tautomer, stereoisomer, or a mixture of stereoisomers thereof,
wherein the compound is labeled with one or more radioactive isotopes;
X2 is

OG Complex Work Unit Chemistry
wherein Y1 is N, and each R9 is independently hydrogen or R6;
each R4 is independently halo, cyano, hydroxy, nitro, amino, alkylamino, dialkylamino, C1-6 alkyl optionally substituted with R5, C1-6 haloalkyl, C1-6 hydroxyalkyl, C 1-6 alkoxy optionally substituted with R5, or C1-6 haloalkoxy;
each R5 is independently halo, cyano, hydroxy, amino, alkylamino, dialkylamino, or C1-6 alkoxy;
each R6 is independently halo, cyano, hydroxy, nitro, amino, alkylamino, dialkylamino, C1-6 alkyl optionally substituted with R7, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 alkoxy optionally substituted with R7, or C1-6 haloalkoxy;
each R7 is independently halo, cyano, hydroxy, amino, alkylamino, dialkylamino, or C1-6 alkoxy; and
m is 0 to 4.