US 12,035,976 B2
Systems and methods for predicting coronary plaque vulnerability from patient specific anatomic image data
Gilwoo Choi, Mountain View, CA (US); Leo Grady, Darien, CT (US); Michiel Schaap, Leiden (NL); and Charles A. Taylor, Atherton, CA (US)
Assigned to HeartFlow, Inc., Mountain View, CA (US)
Filed by HeartFlow, Inc., Mountain View, CA (US)
Filed on May 9, 2023, as Appl. No. 18/314,396.
Application 18/314,396 is a continuation of application No. 17/164,885, filed on Feb. 2, 2021, granted, now 11,678,937.
Application 17/164,885 is a continuation of application No. 15/680,950, filed on Aug. 18, 2017, granted, now 10,939,960, issued on Mar. 9, 2021.
Application 15/680,950 is a continuation of application No. 14/881,989, filed on Oct. 13, 2015, granted, now 9,770,303, issued on Sep. 26, 2017.
Application 14/881,989 is a continuation of application No. 14/254,521, filed on Apr. 16, 2014, granted, now 9,155,512, issued on Oct. 13, 2015.
Claims priority of provisional application 61/917,639, filed on Dec. 18, 2013.
Prior Publication US 2023/0301722 A1, Sep. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 34/10 (2016.01); A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/026 (2006.01); A61B 5/055 (2006.01); A61B 6/00 (2006.01); A61B 6/03 (2006.01); A61B 6/50 (2024.01); A61B 8/12 (2006.01); G06T 7/00 (2017.01); G16H 50/30 (2018.01); G16H 50/50 (2018.01)
CPC A61B 34/10 (2016.02) [A61B 5/0066 (2013.01); A61B 5/02007 (2013.01); A61B 5/026 (2013.01); A61B 5/055 (2013.01); A61B 5/7275 (2013.01); A61B 6/032 (2013.01); A61B 6/503 (2013.01); A61B 6/504 (2013.01); A61B 6/5217 (2013.01); A61B 8/12 (2013.01); G06T 7/0012 (2013.01); G16H 50/30 (2018.01); G16H 50/50 (2018.01); G06T 2207/10104 (2013.01); G06T 2207/10108 (2013.01); G06T 2207/30104 (2013.01); Y02A 90/10 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A computer-implemented method for planning a treatment of cardiovascular disease of a patient, the method comprising:
obtaining, via a processor, patient-specific data from a medical imaging scan of at least a part of the patient's vascular system;
extracting, via the processor, at least one patient-specific geometric feature from the obtained patient-specific data;
determining, via the processor, at least one patient-specific hemodynamic or biomechanical characteristic based on one or more of the obtained data or the patient-specific geometric feature;
for each treatment of a plurality of different treatment options:
adjusting, via the processor, at least one of the patient-specific data, the at least one patient-specific geometric feature, or the at least one patient-specific hemodynamic or biomechanical characteristic so as to simulate application of the treatment to the patient; and
predicting, via the processor, a respective post-treatment coronary plaque vulnerability defining a risk of rupture of one or more regions of plaque present in the patient's vascular system after enactment of the treatment, based on the adjusted one or more of the patient-specific data, the at least one patient-specific geometric feature, or the at least one patient-specific hemodynamic or biomechanical characteristic;
comparing, via the processor, the respective post-treatment coronary plaque vulnerabilities of the plurality of treatment options; and
determining an optimal treatment for the patient based on the comparing.