US 12,359,255 B2
Method for determining decrease in functions of hippocampus by using correlation between micro RNA and NMDA receptor, method for inhibiting decrease in functions, and method for screening for inhibitors of decrease in functions
Keetae Kim, Daegu (KR); Hong Gil Nam, Daegu (KR); and Chand Parvez Danka Mohammed, Daegu (KR)
Assigned to DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY, Daegu (KR); INSTITUTE FOR BASIC SCIENCE, Daejeon (KR); and ANLBIO, Suwon-si (KR)
Filed by DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY, Daegu (KR); INSTITUTE FOR BASIC SCIENCE, Daejeon (KR); and ANLBIO, Suwon-si (KR)
Filed on Feb. 22, 2021, as Appl. No. 17/181,142.
Application 16/889,372 is a division of application No. 15/736,949, granted, now 10,704,099, previously published as PCT/KR2016/006465, filed on Jun. 17, 2016.
Application 17/181,142 is a continuation in part of application No. 16/889,372, filed on Jun. 1, 2020, granted, now 11,359,245.
Prior Publication US 2021/0254161 A1, Aug. 19, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/6883 (2018.01); C12N 15/113 (2010.01); G01N 33/50 (2006.01)
CPC C12Q 1/6883 (2013.01) [C12N 15/113 (2013.01); G01N 33/5023 (2013.01); G01N 33/5058 (2013.01); C12N 2310/11 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01)] 12 Claims
 
1. A method of treating cognitive impairment or Alzheimer's disease, the method comprising administering, to an individual in need thereof, an effective amount of an agent which inhibits an activity of miR-204-5p,
wherein the agent which inhibits an activity of miR-204-5p is a nucleic acid molecule capable of binding to all or part of the nucleotide sequence of miR-204-5p,
wherein the nucleic acid molecule is an oligonucleotide.