US 12,358,867 B1
Peptoid-based inhibitors of the protein arginine methyltransferase (PRMT) family
Bryan Knuckley, Jacksonville, FL (US); Corey P. Causey, Jacksonville, FL (US); and Fatima Khwaja Rehman, Jacksonville, FL (US)
Assigned to University of North Florida Board of Trustees, Jacksonville, FL (US)
Filed by Bryan Knuckley, Jacksonville, FL (US); Corey P. Causey, Jacksonville, FL (US); and Fatima Khwaja Rehman, Jacksonville, FL (US)
Filed on Apr. 23, 2024, as Appl. No. 18/643,330.
Application 18/643,330 is a division of application No. 17/527,475, filed on Nov. 16, 2021, granted, now 11,993,556.
Claims priority of provisional application 63/114,813, filed on Nov. 17, 2020.
Int. Cl. C07C 259/06 (2006.01)
CPC C07C 259/06 (2013.01) 5 Claims
 
1. A compound for inhibiting protein arginine methyltransferase (PRMT) comprising:
a peptide mimetic wherein the peptide mimetic is a peptoid-based inhibitor of PRMT comprising Formula (I)

OG Complex Work Unit Chemistry
wherein R1 is at least one amine monomer;
wherein R2 is at least one amine monomer;
wherein R3 is NH2 or CH2—X;
wherein X is a halogen; and
wherein n is an integer between 1 and 4.