US 12,357,802 B2
Self-actuating articles
Carlo Giovanni Traverso, Newton, MA (US); Alex G. Abramson, St. Louis, MO (US); Ester Caffarel Salvador, Somerville, MA (US); Niclas Roxhed, Bromma (SE); Minsoo Khang, Boston, MA (US); Taylor Bensel, Walpole, MA (US); and Robert S. Langer, Newton, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US); and The Brigham and Women's Hospital, Inc., Boston, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and The Brigham and Women's Hospital, Inc., Boston, MA (US)
Filed on Jun. 1, 2023, as Appl. No. 18/204,882.
Application 18/204,882 is a continuation of application No. 16/614,177, granted, now 11,712,421, previously published as PCT/US2018/033187, filed on May 17, 2018.
Claims priority of provisional application 62/507,647, filed on May 17, 2017.
Claims priority of provisional application 62/507,653, filed on May 17, 2017.
Claims priority of provisional application 62/507,665, filed on May 17, 2017.
Prior Publication US 2024/0024250 A1, Jan. 25, 2024
Int. Cl. A61M 31/00 (2006.01); A61B 5/145 (2006.01); A61B 10/02 (2006.01); A61B 10/06 (2006.01); A61J 3/07 (2006.01); A61K 9/00 (2006.01); A61K 9/48 (2006.01); A61K 38/28 (2006.01); A61M 5/142 (2006.01); A61M 5/145 (2006.01); A61M 5/158 (2006.01); A61M 5/20 (2006.01); A61M 5/32 (2006.01); A61M 37/00 (2006.01); A61N 1/05 (2006.01); A61N 1/32 (2006.01); A61N 1/36 (2006.01)
CPC A61M 31/002 (2013.01) [A61B 5/14503 (2013.01); A61B 5/14539 (2013.01); A61B 10/02 (2013.01); A61J 3/07 (2013.01); A61K 9/0002 (2013.01); A61K 9/0012 (2013.01); A61K 9/0021 (2013.01); A61K 9/0065 (2013.01); A61K 9/0092 (2013.01); A61K 9/4808 (2013.01); A61K 9/4866 (2013.01); A61K 38/28 (2013.01); A61M 5/14276 (2013.01); A61M 5/1454 (2013.01); A61M 5/158 (2013.01); A61M 5/2033 (2013.01); A61M 5/329 (2013.01); A61M 5/3295 (2013.01); A61M 37/0015 (2013.01); A61M 37/0069 (2013.01); A61N 1/325 (2013.01); A61N 1/36007 (2013.01); A61B 2010/0208 (2013.01); A61B 10/0233 (2013.01); A61B 10/06 (2013.01); A61M 2005/14284 (2013.01); A61M 2005/1581 (2013.01); A61M 2005/1585 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01); A61M 2205/0238 (2013.01); A61M 2205/21 (2013.01); A61M 2210/1053 (2013.01); A61M 2210/106 (2013.01); A61N 1/0509 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A self-actuating article for delivery of a therapeutic agent at a location internal to a subject, the self-actuating article comprising:
a tissue interfacing component comprising the therapeutic agent;
a spring operably linked to the tissue interfacing component; and
a degradable support material at least partially encapsulating the spring, such that the spring comprises a stored energy,
wherein, upon at least partial degradation of the degradable support material, the spring at least partially releases the stored energy thereby displacing the tissue interfacing component in the self-actuating article, thereby delivering the therapeutic agent to the location internal to the subject, and
wherein, upon activation of the spring, the spring expands in the direction of a major axis of the tissue interfacing component.