US 12,357,772 B2
Cellular therapy infusion devices, systems, and methods for use
Nikhil S Joshi, San Carlos, CA (US); Marcus Foley, San Jose, CA (US); and Avnesh Thakor, Menlo Park, CA (US)
Assigned to CELLULAR VEHICLES, INC., San Mateo, CA (US)
Filed by CELLULAR VEHICLES INC., San Mateo, CA (US)
Filed on Nov. 7, 2022, as Appl. No. 17/982,477.
Application 17/982,477 is a continuation of application No. 17/824,881, filed on May 25, 2022, granted, now 11,504,485.
Claims priority of provisional application 63/234,426, filed on Aug. 18, 2021.
Claims priority of provisional application 63/291,933, filed on Dec. 20, 2021.
Prior Publication US 2023/0063936 A1, Mar. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 5/48 (2006.01); A61M 5/145 (2006.01); A61M 5/168 (2006.01); A61M 5/315 (2006.01); G16H 20/17 (2018.01); A61M 5/20 (2006.01); A61M 5/31 (2006.01)
CPC A61M 5/484 (2013.01) [A61M 5/1456 (2013.01); A61M 5/16854 (2013.01); A61M 5/31511 (2013.01); G16H 20/17 (2018.01); A61M 2005/2086 (2013.01); A61M 2005/3143 (2013.01); A61M 2205/3368 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A cellular therapy infusion system comprising:
an endplate for accepting and holding a cellular therapy infusion device positioned therein in place, the endplate including an exit port configured, arranged, and positioned to allow a catheter coupled to the cellular therapy infusion device to exit the cellular therapy infusion system via the exit port, the cellular therapy infusion device comprising:
a barrel sized and shaped to accept insertion of a plunger therein and contain a volume of cellular therapy media;
a gasket positioned on an exterior surface of the barrel;
a syringe shaft, a first end of the syringe shaft being physically coupled to, and in liquid communication with, the barrel and a second end of the syringe shaft including a catheter coupling configured to couple to the catheter; and
the plunger positioned within the barrel at a first position, the plunger being configured so that when a compressive force is applied to the plunger, the plunger is translated from the first position to a second position thereby pushing the volume of cellular therapy media from the barrel to the syringe shaft;
a first motor for moving a headplate mechanically coupled thereto;
the headplate mechanically coupled to the motor and configured to apply the compressive force to the plunger responsively to movement of the first motor, the compressive force translating the plunger from the first position to the second position;
a second motor mechanically coupled to and configured to rotate a rotation shaft; and
the rotation shaft being configured to engage the gasket and translate rotation of the rotation shaft by the second motor to the gasket, thereby rotating the barrel.