US 12,357,761 B2
Cell delivery system and methods of operation thereof
Michael McGrogan, San Carlos, CA (US)
Assigned to SanBio, Inc., Oakland, CA (US)
Filed by SanBio, Inc., Mountain View, CA (US)
Filed on Aug. 8, 2022, as Appl. No. 17/818,244.
Application 17/818,244 is a continuation of application No. 16/437,206, filed on Jun. 11, 2019, granted, now 11,439,761.
Application 16/437,206 is a continuation of application No. PCT/US2017/068288, filed on Dec. 22, 2017.
Claims priority of provisional application 62/439,818, filed on Dec. 28, 2016.
Prior Publication US 2022/0379030 A1, Dec. 1, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/28 (2015.01); A61M 5/178 (2006.01); A61M 5/31 (2006.01); A61M 5/315 (2006.01); A61M 5/32 (2006.01)
CPC A61M 5/31531 (2013.01) [A61K 35/28 (2013.01); A61M 5/1782 (2013.01); A61M 5/3129 (2013.01); A61M 5/315 (2013.01); A61M 5/32 (2013.01); A61M 2202/09 (2013.01); A61M 2209/045 (2013.01); A61M 2209/088 (2013.01); A61M 2210/0693 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of treating a traumatic brain injury in a subject, the method comprising:
removing a plunger of a syringe from a barrel of the syringe, wherein the barrel has a proximal end, a distal end, and a lumen in between the proximal end and the distal end;
filling at least part of the lumen with a cell suspension comprising a therapeutically effective amount of cells through an opening at the proximal end and reinserting the plunger, wherein the cells are descendant from mesenchymal stem cells transiently-transfected by a polynucleotide encoding a Notch intracellular domain;
coupling an implantation device to the syringe at the distal end of the barrel;
injecting the cell suspension into the subject using the syringe and the implantation device at multiple deposit sites in the subject; and
rotating at least one of the syringe and the implantation device about a longitudinal axis after each injection at a deposit site of the multiple deposit sites.