US 12,357,748 B2
Microdosing
Michael Adler, Basel (CH); Joerg Luemkemann, Basel (CH); Hanns-Christian Mahler, Basel (CH); Denis Luthringer, Basel (CH); Alexander Meyer, Basel (CH); Adeline Boillon, Basel (CH); Anke Dorn, Basel (CH); Karoline Bechthold-Peters, Basel (CH); Tim Dreckmann, Basel (CH); and Andreas Ernst, Freiburg (DE)
Assigned to HOFFMANN-LA ROCHE INC., Little Falls, NJ (US)
Appl. No. 17/286,242
Filed by HOFFMANN-LA ROCHE INC., Little Falls, NJ (US)
PCT Filed Oct. 18, 2019, PCT No. PCT/EP2019/078397
§ 371(c)(1), (2) Date Apr. 16, 2021,
PCT Pub. No. WO2020/079236, PCT Pub. Date Apr. 23, 2020.
Claims priority of application No. 18201464 (EP), filed on Oct. 19, 2018.
Prior Publication US 2021/0346598 A1, Nov. 11, 2021
Int. Cl. A61M 5/142 (2006.01); A61M 5/315 (2006.01); F04B 43/12 (2006.01)
CPC A61M 5/14228 (2013.01) [A61M 5/31531 (2013.01); A61M 5/31556 (2013.01); F04B 43/12 (2013.01); A61M 2205/0294 (2013.01); A61M 2205/3334 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A dosing system for transferring an aseptic fluid in dosages into a container, comprising:
a peristaltic pump with a tubing,
a liquid flow measurement sensor, and
a control unit,
wherein the peristaltic pump is configured to provide a filling accuracy of ±3 μL for fill volumes of the aseptic fluid of less than 100 μL by
the tubing having an internal diameter of between 1.6 mm and 0.8 mm,
the liquid flow measurement sensor being connected to the peristaltic pump and configured to report a volume of the aseptic fluid passed through the peristaltic pump, wherein the liquid flow measurement sensor is a capacitive pressure sensor, and
the control unit being coupled to the peristaltic pump and coupled to the liquid flow measurement sensor, wherein the control unit is configured to receive a data signal from the liquid flow measurement sensor, to evaluate the received data signal, and to adapt the peristaltic pump in accordance with the evaluated data signal.