US 12,357,676 B2
Method of using NAP-2 and TGF-α to improve cardiac function
Atta Behfar, Rochester, MN (US); Andre Terzic, Rochester, MN (US); and Ruben Jose Crespo-Diaz, Rochester, MN (US)
Assigned to Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed by Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed on Jul. 7, 2022, as Appl. No. 17/859,130.
Application 16/891,344 is a division of application No. 15/850,276, filed on Dec. 21, 2017, granted, now 10,682,394, issued on Jun. 16, 2020.
Application 15/850,276 is a division of application No. 14/916,548, granted, now 9,884,090, issued on Feb. 6, 2018, previously published as PCT/US2014/053860, filed on Sep. 3, 2014.
Application 17/859,130 is a continuation of application No. 16/891,344, filed on Jun. 3, 2020, granted, now 11,413,330.
Claims priority of provisional application 61/873,122, filed on Sep. 3, 2013.
Prior Publication US 2022/0339253 A1, Oct. 27, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 48/00 (2006.01); A61P 9/10 (2006.01); A61K 38/45 (2006.01); A61P 37/02 (2006.01); C07K 14/495 (2006.01); C07K 14/52 (2006.01); G01N 33/68 (2006.01)
CPC A61K 38/195 (2013.01) [A61K 38/1841 (2013.01); A61K 48/0075 (2013.01); A61P 9/10 (2018.01); A61K 38/45 (2013.01); A61K 48/005 (2013.01); A61P 37/02 (2018.01); C07K 14/495 (2013.01); C07K 14/522 (2013.01); C12Y 207/10001 (2013.01); G01N 33/6887 (2013.01); G01N 2800/325 (2013.01); G01N 2800/50 (2013.01)] 12 Claims
 
1. A method for improving cardiac function in a subject after myocardial infarction, wherein the method comprises:
administering to the subject a composition comprising a transforming growth factor-α (TGF-α) polypeptide; and
administering to the subject a composition comprising a neutrophil-activating protein-2 (NAP-2) polypeptide;
thereby improving cardiac function of the subject.