US 12,357,617 B2
Discovery of novel anti-infectives for gram negative pathogens
Philip Bulterys, Los Angeles, CA (US); Jeffery F. Miller, Santa Monica, CA (US); Robert D. Damoiseaux, Beverly Hills, CA (US); and Christopher Todd French, Los Angeles, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Appl. No. 17/279,015
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Oct. 4, 2019, PCT No. PCT/US2019/054824
§ 371(c)(1), (2) Date Mar. 23, 2021,
PCT Pub. No. WO2020/072976, PCT Pub. Date Apr. 9, 2020.
Claims priority of provisional application 62/741,393, filed on Oct. 4, 2018.
Prior Publication US 2022/0031672 A1, Feb. 3, 2022
Int. Cl. A61K 31/436 (2006.01); A61P 31/04 (2006.01)
CPC A61K 31/436 (2013.01) [A61P 31/04 (2018.01)] 6 Claims
 
1. A method of inhibiting intercellular spreading of Burkholderia pseudomallei or Burkholderia mallei bacteria, the method comprising contacting the Burkholderia pseudomallei or Burkholderia mallei bacteria with Burkfloxacin;
wherein the Burkholderia pseudomallei or Burkholderia mallei bacteria are contacted with amounts of Burkfloxacin sufficient to inhibit intercellular spreading of the Burkholderia pseudomallei or Burkholderia mallei bacteria; and
Burkfloxacin is administered to a patient diagnosed with melioidosis or glanders disease.