US 12,357,602 B2
Compositions comprising encapsulated tretinoin
Ofer Toledano, Kfar Saba (IL); Karine Neimann, Ness Ziona (IL); Maya Erlich, Ness Ziona (IL); and Dorit Marco, Rehovot (IL)
Assigned to Mayne Pharma LLC, Raleigh, NC (US)
Filed by SOL-GEL TECHNOLOGIES LTD., Ness Ziona (IL)
Filed on Jul. 12, 2018, as Appl. No. 16/033,260.
Claims priority of provisional application 62/531,402, filed on Jul. 12, 2017.
Prior Publication US 2019/0015366 A1, Jan. 17, 2019
Int. Cl. A61K 31/202 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/107 (2006.01); A61K 9/50 (2006.01); A61K 31/203 (2006.01)
CPC A61K 31/202 (2013.01) [A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 9/107 (2013.01); A61K 9/501 (2013.01); A61K 31/203 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A composition comprising:
microcapsules comprising tretinoin, wherein:
said microcapsules comprise a core containing tretinoin dispersed in an oil and a phase changing material and a metal oxide shell; and
wherein said tretinoin is in solid form and said microcapsules have a D90 between 30 μm to 50 μm; and
wherein said tretinoin is in the range of 0.01%-0.1% by weight of the composition; and
microcapsules comprising solid benzoyl peroxide with a metal oxide shell; wherein said benzoyl peroxide is in an amount of 3% by weight of the composition;
wherein degradation of said tretinoin is less than 2.5% after two weeks storage at 40° C. and 75% relative humidity.