US 12,357,599 B2
Prodrugs of treprostinil
Hitesh Batra, Herndon, VA (US); Liang Guo, Vienna, VA (US); Patrick Poisson, Chapel Hill, NC (US); Sri Harsha Tummala, Owings Mills, MD (US); and Elizabeth Ann Harris, Lagrangeville, NY (US)
Assigned to United Therapeutics Corporation, Silver Spring, MD (US); and MannKind Corporation, Westlake Village, CA (US)
Filed by United Therapeutics Corporation, Silver Spring, MD (US); and MannKind Corporation, Westlake Village, CA (US)
Filed on Oct. 17, 2023, as Appl. No. 18/488,342.
Application 18/488,342 is a continuation of application No. 17/342,377, filed on Jun. 8, 2021, granted, now 11,793,780.
Claims priority of provisional application 63/036,561, filed on Jun. 9, 2020.
Prior Publication US 2024/0058287 A1, Feb. 22, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/192 (2006.01); A61K 47/54 (2017.01)
CPC A61K 31/192 (2013.01) [A61K 47/545 (2017.08)] 6 Claims
 
1. A compound of (4a) or (4b):

OG Complex Work Unit Chemistry
wherein R1 is a carboxylic acid protecting group, R2 is H or a hydroxyl protecting group, R3 is H or a hydroxyl protecting group, and R5 is a polymeric carrier.